Sökning: onr:"swepub:oai:gup.ub.gu.se/327591" >
Inference of gliobl...
Inference of glioblastoma migration and proliferation rates using single time-point images
-
- Rosén, Emil (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
- Mangukiya, Hitesh, Researcher (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
- Elfineh, Lioudmila (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
visa fler...
-
- Stockgard, R. (författare)
- Uppsala universitet,Neuroonkologi och neurodegeneration,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
- Krona, Cecilia, 1976- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
- Gerlee, Philip, 1980 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Math Sci, Gothenburg, Sweden.;Univ Gothenburg, Math Sci, Gothenburg, Sweden.
-
- Nelander, Sven (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi och neurodegeneration,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
-
visa färre...
-
Uppsala universitet Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden (creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
-
Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 6:1
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://doi.org/10.1...
-
https://uu.diva-port... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cancer cell migration is a driving mechanism of invasion in solid malignant tumors. Anti-migratory treatments provide an alternative approach for managing disease progression. However, we currently lack scalable screening methods for identifying novel anti-migratory drugs. To this end, we develop a method that can estimate cell motility from single end-point images in vitro by estimating differences in the spatial distribution of cells and inferring proliferation and diffusion parameters using agent-based modeling and approximate Bayesian computation. To test the power of our method, we use it to investigate drug responses in a collection of 41 patient-derived glioblastoma cell cultures, identifying migration-associated pathways and drugs with potent anti-migratory effects. We validate our method and result in both in silico and in vitro using time-lapse imaging. Our proposed method applies to standard drug screen experiments, with no change needed, and emerges as a scalable approach to screen for anti-migratory drugs. The spatial positioning of cultured glioblastoma cells is used to estimate cell motility and drug effects from single end-point images in vitro.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
Nyckelord
- cancer-cell-migration
- glioma-cells
- invasion
- microscopy
- tumor
- invasiveness
- paclitaxel
- inhibitors
- particles
- dasatinib
- Life Sciences & Biomedicine - Other Topics
- Science & Technology - Other
- Topics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas