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Development of earl...
Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments
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- Bargheet, A. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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- Klingenberg, C. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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- Esaiassen, E. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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- Hjerde, E. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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- Cavanagh, J. P. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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- Bengtsson-Palme, Johan, 1985 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Pettersen, V. K. (författare)
- Universitetet i Tromsø – Norges arktiske universitet,University of Tromsø – The Arctic University of Norway
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Ebiomedicine. - 2352-3964. ; 92
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Abstract
Ämnesord
Stäng
- Background Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota’s core characteristics, gut resistome and mobilome, remains nascent. Methods We analysed metagenomic data from a longitudinal observational study in six Norwegian neonatal intensive care units to describe the bacterial microbiota of infants of varying GA and receiving different treatments. The cohort consisted of probiotic-supplemented and antibiotic-exposed extremely preterm infants (n = 29), antibiotic-exposed very preterm (n = 25), antibiotic-unexposed very preterm (n = 8), and antibiotic-unexposed full-term (n = 10) infants. The stool samples were collected on days of life 7, 28, 120, and 365, and DNA extraction was followed by shotgun metagenome sequencing and bioinformatical analysis. Findings The top predictors of microbiota maturation were hospitalisation length and GA. Probiotic administration rendered the gut microbiota and resistome of extremely preterm infants more alike to term infants on day 7 and ameliorated GA-driven loss of microbiota interconnectivity and stability. GA, hospitalisation, and both microbiota-modifying treatments (antibiotics and probiotics) contributed to an elevated carriage of mobile genetic elements in preterm infants compared to term controls. Finally, Escherichia coli was associated with the highest number of antibiotic-resistance genes, followed by Klebsiella pneumoniae and Klebsiella aerogenes. Interpretation Prolonged hospitalisation, antibiotics, and probiotic intervention contribute to dynamic alterations in resistome and mobilome, gut microbiota characteristics relevant to infection risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Extremely preterm infants
- Probiotics
- Gestational age
- Gut microbiota
- Resistome
- Mobilome
- resistance
- supplementation
- association
- General & Internal Medicine
- Research & Experimental Medicine
- Extremely preterm infants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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