SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/328508"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/328508" > Mediating role of a...

  • Björnson, Elias,1988Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden. (författare)

Mediating role of atherogenic lipoproteins in the relationship between liver fat and coronary artery calcification

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Springer Nature,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/328508
  • https://gup.ub.gu.se/publication/328508URI
  • https://doi.org/10.1038/s41598-023-39390-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-511149URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Non-alcoholic fatty liver disease (NAFLD) is associated with increased secretion of apoB-containing lipoproteins and increased risk of coronary heart disease (CHD). ApoB-containing lipoproteins include low-density lipoproteins (LDLs) and triglyceride-rich lipoproteins (TRLs); and since both LDLs and TRLs are causally related to CHD, they may mediate a portion of the increased risk of atherosclerosis seen in people with NAFLD. In a cohort of 4161 middle aged men and women, we performed mediation analysis in order to quantify the mediating effect of apoB-containing lipoproteins in the relationship between liver fat and atherosclerosis-as measured by coronary artery calcium score (CACS). We found plasma apoB to mediate 17.6% (95% CI 11-24) of the association between liver fat and CACS. Plasma triglycerides and TRL-cholesterol (both proximate measures of TRL particles) mediated 22.3% (95% CI 11-34) and 21.6% (95% CI 10-33) of the association respectively; whereas LDL-cholesterol mediated 5.4% (95% CI 2.0-9.4). In multivariable models, the mediating effect of TRL-cholesterol and plasma triglycerides showed, again, a higher degree of mediation than LDL-cholesterol, corroborating the results seen in the univariable models. In summary, we find around 20% of the association between liver fat and CACS to be mediated by apoB-containing lipoproteins. In addition, we find that TRLs mediate the majority of this effect whereas LDLs mediate a smaller effect. These results explain part of the observed CAD-risk burden for people with NAFLD and further suggest that TRL-lowering may be particularly beneficial to mitigate NAFLD-associated coronary artery disease risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Samaras, DimitriosGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden. (författare)
  • Adiels, Martin,1976Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Wallenberg Laboratory,Institute of Medicine, School of Public Health and Community Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Gothenburg, Sweden.(Swepub:gu)xadima (författare)
  • Kullberg, Joel,1979-Uppsala universitet,Radiologi,Antaros Med, S-43183 Mölndal, Sweden.(Swepub:uu)jokul377 (författare)
  • Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xbafre (författare)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Physiol, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xbgort (författare)
  • Gummesson, Anders,1973Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Univ Hosp, ahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Clin Genet, Reg Vastra Gotaland, S-41345 Gothenburg, Sweden.(Swepub:gu)xguman (författare)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Scientific Reports: Springer Nature13:12045-2322

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy