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Sökning: onr:"swepub:oai:gup.ub.gu.se/329201" > Outcomes in Patient...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004744naa a2200541 4500
001oai:gup.ub.gu.se/329201
003SwePub
008240528s2023 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3292012 URI
0247 a https://doi.org/10.1001/jamaneurol.2023.32402 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Misra, Shubham4 aut
2451 0a Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis.
264 1c 2023
520 a Published data about the impact of poststroke seizures (PSSs) on the outcomes of patients with stroke are inconsistent and have not been systematically evaluated, to the authors' knowledge.To investigate outcomes in people with PSS compared with people without PSS.MEDLINE, Embase, PsycInfo, Cochrane, LILACS, LIPECS, and Web of Science, with years searched from 1951 to January 30, 2023.Observational studies that reported PSS outcomes.The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used for abstracting data, and the Joanna Briggs Institute tool was used for risk-of-bias assessment. Data were reported as odds ratio (OR) and standardized mean difference (SMD) with a 95% CI using a random-effects meta-analysis. Publication bias was assessed using funnel plots and the Egger test. Outlier and meta-regression analyses were performed to explore the source of heterogeneity. Data were analyzed from November 2022 to January 2023.Measured outcomes were mortality, poor functional outcome (modified Rankin scale [mRS] score 3-6), disability (mean mRS score), recurrent stroke, and dementia at patient follow-up.The search yielded 71 eligible articles, including20110 patients with PSS and 1166085 patients without PSS. Of the participants with PSS, 1967 (9.8%) had early seizures, and 10605 (52.7%) had late seizures. The risk of bias was high in 5 studies (7.0%), moderate in 35 (49.3%), and low in 31 (43.7%). PSSs were associated with mortality risk (OR, 2.1; 95% CI, 1.8-2.4), poor functional outcome (OR, 2.2; 95% CI, 1.8-2.8), greater disability (SMD, 0.6; 95% CI, 0.4-0.7), and increased dementia risk (OR, 3.1; 95% CI, 1.3-7.7) compared with patients without PSS. In subgroup analyses, early seizures but not late seizures were associated with mortality (OR, 2.4; 95% CI, 1.9-2.9 vs OR, 1.2; 95% CI, 0.8-2.0) and both ischemic and hemorrhagic stroke subtypes were associated with mortality (OR, 2.2; 95% CI, 1.8-2.7 vs OR, 1.4; 95% CI, 1.0-1.8). In addition, early and late seizures (OR, 2.4; 95% CI, 1.6-3.4 vs OR, 2.7; 95% CI, 1.8-4.1) and stroke subtypes were associated with poor outcomes (OR, 2.6; 95% CI, 1.9-3.7 vs OR, 1.9; 95% CI, 1.0-3.6).Results of this systematic review and meta-analysis suggest that PSSs were associated with significantly increased mortality and severe disability in patients with history of stroke. Unraveling these associations is a high clinical and research priority. Trials of interventions to prevent seizures may be warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Kasner, Scott E4 aut
7001 a Dawson, Jesse4 aut
7001 a Tanaka, Tomotaka4 aut
7001 a Zhao, Yize4 aut
7001 a Zaveri, Hitten P4 aut
7001 a Eldem, Ece4 aut
7001 a Vazquez, Juan4 aut
7001 a Silva, Lucas Scárdua4 aut
7001 a Mohidat, Saba4 aut
7001 a Hickman, L Brian4 aut
7001 a Khan, Erum I4 aut
7001 a Funaro, Melissa C4 aut
7001 a Nicolo, John-Paul4 aut
7001 a Mazumder, Rajarshi4 aut
7001 a Yasuda, Clarissa Lin4 aut
7001 a Stibrant Sunnerhagen, Katharina,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xstika
7001 a Ihara, Masafumi4 aut
7001 a Ross, Joseph S4 aut
7001 a Liebeskind, David S4 aut
7001 a Kwan, Patrick4 aut
7001 a Quinn, Terence J4 aut
7001 a Engel, Jerome4 aut
7001 a Mishra, Nishant K4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org
7730 t JAMA neurologyg 80:11, s. 1155-1165q 80:11<1155-1165x 2168-6149x 2168-6157
8564 8u https://gup.ub.gu.se/publication/329201
8564 8u https://doi.org/10.1001/jamaneurol.2023.3240

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