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Very Early-Life Ris...
Very Early-Life Risk Factors for Developing Dementia: Evidence From Full Population Registers
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- Fischer, Martin (författare)
- Lund University,Lunds universitet,Centrum för ekonomisk demografi,Ekonomihögskolan,Hälsoekonomi,Forskargrupper vid Lunds universitet,Centre for Economic Demography,Lund University School of Economics and Management, LUSEM,Health Economics,Lund University Research Groups,Rheinisch-Westfälisches Institut für Wirtschaftsforschung
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- Lövdén, Martin, 1972 (författare)
- Karolinska Institutet,University of Gothenburg,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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- Nilsson, Therese (författare)
- Lund University,Lunds universitet,Centrum för ekonomisk demografi,Ekonomihögskolan,Nationalekonomiska institutionen,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Centre for Economic Demography,Lund University School of Economics and Management, LUSEM,Department of Economics,Lund University School of Economics and Management, LUSEM,LU Profile Area: Proactive Ageing,Lund University Profile areas
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Seblova, D. (författare)
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- Seblova, Nika (författare)
- Charles University in Prague
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Journals of Gerontology Series B-Psychological Sciences and Social Sciences. - 1079-5014 .- 1758-5368. ; 78:12, s. 2131-2140
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Abstract
Ämnesord
Stäng
- Objectives: Very early-life conditions are recognized as critical for healthy brain development. This study assesses early-life risk factors for developing dementia. In the absence of historical medical birth records, we leverage an alternative full population approach using demographic characteristics obtained from administrative data to derive proxy indicators for birth complications and unfavorable birth outcomes. We use proxy variables to investigate the impact of early-life risk factors on dementia risk.Methods: We use administrative individual-level data for full cohorts born 1932-1950 in Sweden with multigenerational linkages. Records on hospitalization and mortality are used to identify dementia cases. We derive 3 birth risk factors based on demographic characteristics: advanced maternal age, narrow sibling spacing, and twin births, and apply survival analysis to evaluate long-term effects on dementia risk. We control for confounding using multiple indicators for socio-economic status (SES), including parental surnames, and by implementing a sibling design. As comparison exposure, we add low education from the 1970 Census.Results: The presence of at least 1 birth risk factor increases dementia risk (HR = 1.059; 95% CI: 1.034, 1.085). The occurrence of twin births poses a particularly heightened risk (HR = 1.166; 95% CI: 1.084, 1.255).Discussion: Improvements to the very early-life environment hold significant potential to mitigate dementia risk. A comparison to the influence of low education on dementia (the largest known modifiable risk factor) suggests that demographic birth characteristics are of relevant effect sizes. Our findings underscore the relevance of providing assistance for births experiencing complications and adverse health outcomes to reduce dementia cases.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Ekonomi och näringsliv -- Nationalekonomi (hsv//swe)
- SOCIAL SCIENCES -- Economics and Business -- Economics (hsv//eng)
Nyckelord
- Birth characteristics
- Dementia risk
- Demographic risk factors
- Early
- life
- people born
- performance
- cohort
- birth
- health
- age
- Geriatrics & Gerontology
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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