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Long-term outcome a...
Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy
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- Berndsen, Marta, 1986 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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Renberg, Sara (författare)
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Hølmebakk, Toto (författare)
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Hancke, Emma (författare)
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Puls, Florian (författare)
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Karlsson, Fredrik (författare)
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Stoldt, Stephan (författare)
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Bjerkehagen, Bodil (författare)
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- Haglund de Flon, Felix (författare)
- Karolinska Institutet
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- Muth, Andreas, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Papakonstantinou, Andri (författare)
- Karolinska Institutet
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Boye, Kjetil (författare)
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- Lindskog, Stefan (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: The British journal of surgery. - 1365-2168. ; 110:12, s. 1857-1862
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Gastrointestinal stromal tumour (GIST) is the most common intra-abdominal sarcoma. Risk classification systems, commonly the modified National Institutes of Health consensus criteria, identify tumour properties relating to patient outcomes. However, owing to limited long-term evidence, most guidelines recommend up to 10-year follow-up for all risk groups except very low-risk GIST. METHODS: This retrospective multicentre study included patients who had complete resection of primary, non-metastatic GIST from three Scandinavian sarcoma centres: Gothenburg (2004-2020), Stockholm (2000-2019), and Oslo (2000-2017). Medical records were reviewed for clinical details regarding diagnosis, treatment, and follow-up, and recurrence-free and disease-specific survival evaluated. RESULTS: The total cohort consisted of 1213 patients with GIST. High-risk patients and those treated with tyrosine kinase inhibitors were excluded. The remaining 649 patients were included in the present analysis: 118 with very low-, 381 with low-, and 150 with intermediate-risk GISTs. Five-year recurrence-free survival rates were 100, 98.5, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.246). Disease-specific survival rates 10 years after surgery were 100, 98.4, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.262). CONCLUSION: Patients with completely resected non-high-risk GISTs have an excellent long-term outcome, irrespective of risk group. Follow-up programmes to detect disease recurrences in these patients are probably not indicated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Berndsen, Marta, ...
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Renberg, Sara
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Hølmebakk, Toto
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Hancke, Emma
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Puls, Florian
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Karlsson, Fredri ...
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visa fler...
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Stoldt, Stephan
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Bjerkehagen, Bod ...
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Haglund de Flon, ...
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Muth, Andreas, 1 ...
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Papakonstantinou ...
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Boye, Kjetil
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Lindskog, Stefan
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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The British jour ...
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Göteborgs universitet
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Karolinska Institutet