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Ultra-high static m...
Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR signaling
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Gu, H. (författare)
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Fu, Y. F. (författare)
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Yu, B. (författare)
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visa fler...
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Luo, L. (författare)
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Kang, D. Q. (författare)
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Xie, M. M. (författare)
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Jing, Y. K. (författare)
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Chen, Q. Y. (författare)
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Zhang, X. (författare)
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Lai, J. (författare)
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Guan, F. (författare)
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- Forsman, Huamei (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Shi, J. M. (författare)
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Yang, L. (författare)
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Lei, J. H. (författare)
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Du, X. R. (författare)
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Zhang, X. (författare)
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Liu, C. H. (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Medcomm. ; 4:5
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To increase the imaging resolution and detection capability, the field strength of static magnetic fields (SMFs) in magnetic resonance imaging (MRI) has significantly increased in the past few decades. However, research on the side effects of high magnetic field is still very inadequate and the effects of SMF above 1 T (Tesla) on B cells have never been reported. Here, we show that 33.0 T ultra-high SMF exposure causes immunosuppression and disrupts B cell differentiation and signaling. 33.0 T SMF treatment resulted in disturbance of B cell peripheral differentiation and antibody secretion and reduced the expression of IgM on B cell membrane, and these might be intensity dependent. In addition, mice exposed to 33.0 T SMF showed inhibition on early activation of B cells, including B cell spreading, B cell receptor clustering and signalosome recruitment, and depression of both positive and negative molecules in the proximal BCR signaling, as well as impaired actin reorganization. Sequencing and gene enrichment analysis showed that SMF stimulation also affects splenic B cells' transcriptome and metabolic pathways. Therefore, in the clinical application of MRI, we should consider the influence of SMF on the immune system and choose the optimal intensity for treatment. 33.0 T SMF treatment resulted in disturbance of B cell peripheral differentiation and antibody secretion, but lower magnetic fields, including 28.7, 17.8, or the 11.2 T SMFs had much less or no such effects. 33.0 T SMF treatment induced downregulate BCR proximal signaling and impaired F-actin remodeling related BCR clustering. SMF stimulation affected the transcriptome and metabolic pathways of B cells.image.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- metabolism
- activation
- exposure
- glucose
- system
- serum
- wasp
- Research & Experimental Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gu, H.
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Fu, Y. F.
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Yu, B.
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Luo, L.
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Kang, D. Q.
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Xie, M. M.
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visa fler...
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Jing, Y. K.
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Chen, Q. Y.
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Zhang, X.
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Lai, J.
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Guan, F.
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Forsman, Huamei
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Shi, J. M.
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Yang, L.
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Lei, J. H.
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Du, X. R.
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Liu, C. H.
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
- Medcomm
- Av lärosätet
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Göteborgs universitet