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Structure and Role ...
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Olofsson, Sigvard,1948Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; email:
(författare)
Structure and Role of O-Linked Glycans in Viral Envelope Proteins
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:gup.ub.gu.se/330727
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https://gup.ub.gu.se/publication/330727URI
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https://doi.org/10.1146/annurev-virology-111821-121007DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215100URI
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N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-glycan heterogeneity. O-glycans are organized as solitary glycans or in clusters of multiple glycans forming mucin-like domains. They are functional both in the viral life cycle and in viral colonization of their host. Negatively charged O-glycans are crucial for the interactions between glycosaminoglycan-binding viruses and their host. A novel mechanism, based on controlled electrostatic repulsion, explains how such viruses solve the conflict between optimized viral attachment to target cells and efficient egress of progeny virus. Conserved solitary O-glycans appear important for viral uptake in target cells by contributing to viral envelope fusion. Dual roles of viral O-glycans in the host B cell immune response, either epitope blocking or epitope promoting, may be exploitable for vaccine development. Finally, specific virus-induced O-glycans may be involved in viremic spread.
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Bally, MartaUmeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)maba0261
(författare)
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Trybala, Edward,1955Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; email: sigvard.olofsson@gu.se(Swepub:gu)xtryed
(författare)
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Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; email: sigvard.olofsson@gu.se(Swepub:gu)xberto
(författare)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annual Review of Virology: Annual Reviews10:1, s. 283-3042327-056X
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Ingår i:Annual review of virology: Annual Reviews10:1, s. 283-3042327-0578
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