Sökning: onr:"swepub:oai:gup.ub.gu.se/330985" > Combined immunother...
Fältnamn | Indikatorer | Metadata |
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000 | 05194naa a2201033 4500 | |
001 | oai:gup.ub.gu.se/330985 | |
003 | SwePub | |
008 | 240910s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3309852 URI |
024 | 7 | a https://doi.org/10.1158/2159-8290.CD-23-05592 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Das, Anirban4 aut |
245 | 1 0 | a Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: A report from the International RRD Consortium. |
264 | 1 | c 2024 |
520 | a Immune-checkpoint inhibition (ICI) is effective for replication-repair deficient, high-grade gliomas (RRD-HGG). Clinical/biologic impact of immune-directed approaches after failing ICI-monotherapy are unknown. We performed an international study on 75 patients treated with anti-PD1; 20 are progression-free (median follow-up: 3.7-years). After 2nd-progression/recurrence (n=55), continuing ICI-based salvage prolonged survival to 11.6-months (n=38; p<0.001), particularly for those with extreme mutation burden (p=0.03). Delayed, sustained responses were observed, associated with changes in mutational spectra and immune-microenvironment. Response to re-irradiation was explained by an absence of deleterious post-radiation indel signatures (ID8). Increased CTLA4-expression over time, and subsequent CTLA4-inhibition resulted in response/stable disease in 75%. RAS-MAPK-pathway inhibition led to reinvigoration of peripheral immune and radiological responses. Local (flare) and systemic immune adverse events were frequent (biallelic mismatch-repair deficiency > Lynch syndrome). We provide mechanistic rationale for the sustained benefit in RRD-HGG from immune-directed/ synergistic salvage therapies. Future approaches need to be tailored to patient and tumor biology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Fernandez, Nicholas R4 aut |
700 | 1 | a Levine, Adrian4 aut |
700 | 1 | a Bianchi, Vanessa4 aut |
700 | 1 | a Stengs, Lucie K4 aut |
700 | 1 | a Chung, Jiil4 aut |
700 | 1 | a Negm, Logine4 aut |
700 | 1 | a Dimayacyac, Jose Rafael4 aut |
700 | 1 | a Chang, Yuan4 aut |
700 | 1 | a Nobre, Liana4 aut |
700 | 1 | a Ercan, Ayse B4 aut |
700 | 1 | a Sanchez-Ramirez, Santiago4 aut |
700 | 1 | a Sudhaman, Sumedha4 aut |
700 | 1 | a Edwards, Melissa4 aut |
700 | 1 | a Larouche, Valerie4 aut |
700 | 1 | a Samuel, David4 aut |
700 | 1 | a Van Damme, An4 aut |
700 | 1 | a Gass, David4 aut |
700 | 1 | a Ziegler, David S4 aut |
700 | 1 | a Bielack, Stefan S4 aut |
700 | 1 | a Koschmann, Carl4 aut |
700 | 1 | a Zelcer, Shayna4 aut |
700 | 1 | a Yalon-Oren, Michal4 aut |
700 | 1 | a Campino, Gadi Abede4 aut |
700 | 1 | a Sarosiek, Tomasz4 aut |
700 | 1 | a Nichols, Kim E4 aut |
700 | 1 | a Loret De Mola, Rebecca4 aut |
700 | 1 | a Bielamowicz, Kevin4 aut |
700 | 1 | a Sabel, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xsabma |
700 | 1 | a Frojd, Charlotta A4 aut |
700 | 1 | a Wood, Matthew D4 aut |
700 | 1 | a Glover, Jason M4 aut |
700 | 1 | a Lee, Yi-Yen4 aut |
700 | 1 | a Vanan, Magimairajan4 aut |
700 | 1 | a Adamski, Jenny K4 aut |
700 | 1 | a Perreault, Sebastien4 aut |
700 | 1 | a Chamdine, Omar4 aut |
700 | 1 | a Hjort, Magnus Aasved4 aut |
700 | 1 | a Zapotocky, Michal4 aut |
700 | 1 | a Carceller, Fernando4 aut |
700 | 1 | a Wright, Erin4 aut |
700 | 1 | a Fedorakova, Ivana4 aut |
700 | 1 | a Lossos, Alexander4 aut |
700 | 1 | a Tanaka, Ryuma4 aut |
700 | 1 | a Osborn, Michael4 aut |
700 | 1 | a Blumenthal, Deborah T4 aut |
700 | 1 | a Aronson, Melyssa4 aut |
700 | 1 | a Bartels, Ute4 aut |
700 | 1 | a Huang, Annie4 aut |
700 | 1 | a Ramaswamy, Vijay4 aut |
700 | 1 | a Malkin, David4 aut |
700 | 1 | a Shlien, Adam4 aut |
700 | 1 | a Villani, Anita4 aut |
700 | 1 | a Dirks, Peter B4 aut |
700 | 1 | a Pugh, Trevor J4 aut |
700 | 1 | a Getz, Gad4 aut |
700 | 1 | a Maruvka, Yosef E4 aut |
700 | 1 | a Tsang, Derek S4 aut |
700 | 1 | a Ertl-Wagner, Birgit4 aut |
700 | 1 | a Hawkins, Cynthia4 aut |
700 | 1 | a Bouffet, Eric4 aut |
700 | 1 | a Morgenstern, Daniel A4 aut |
700 | 1 | a Tabori, Uri4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för pediatrik4 org |
773 | 0 | t Cancer discoveryg 14:2, s. 258-273q 14:2<258-273x 2159-8290 |
856 | 4 8 | u https://gup.ub.gu.se/publication/330985 |
856 | 4 8 | u https://doi.org/10.1158/2159-8290.CD-23-0559 |
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