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Age-related differe...
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions
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- Vereb, D. (författare)
- Karolinska Institutet,Karolinska Institute
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- Mijalkov, M. (författare)
- Karolinska Institutet,Karolinska Institute
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- Canal-Garcia, A. (författare)
- Karolinska Institutet,Karolinska Institute
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- Chang, Yu-Wei (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)
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- Gomez-Ruiz, Emiliano (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)
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- Gerboles, B. Z. (författare)
- Karolinska Institutet,Karolinska Institute
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- Kivipelto, M. (författare)
- Karolinska Institute,University of Eastern Finland
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- Svenningsson, P. (författare)
- Karolinska Institutet,Karolinska Institute,University of Eastern Finland
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- Zetterberg, Henrik, 1973 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Hong Kong Center for Neurodegenerative Diseases,Sahlgrenska Academy,University College London,University of Wisconsin-Madison
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- Volpe, Giovanni, 1979 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU)
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- Betts, M. (författare)
- Otto von Guericke University Magdeburg
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- Jacobs, H. I. L. (författare)
- Massachusetts General Hospital,Maastricht University
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- Pereira, Joana B. (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: eLife. - 2050-084X. ; 12
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging, and whether it is associated with cognition and mood. Here, we employ a gradient-based approach to characterize the functional heterogeneity in the organization of the LC over aging using 3T resting-state fMRI in a population-based cohort aged from 18 to 88 years of age (Cambridge Centre for Ageing and Neuroscience cohort, n=618). We show that the LC exhibits a rostro-caudal functional gradient along its longitudinal axis, which was replicated in an independent dataset (Human Connectome Project [HCP] 7T dataset, n=184). Although the main rostro-caudal direction of this gradient was consistent across age groups, its spatial features varied with increasing age, emotional memory, and emotion regulation. More specifically, a loss of rostral-like connectivity, more clustered functional topography, and greater asymmetry between right and left LC gradients was associated with higher age and worse behavioral performance. Furthermore, participants with higher-than-normal Hospital Anxiety and Depression Scale (HADS) ratings exhibited alterations in the gradient as well, which manifested in greater asymmetry. These results provide an in vivo account of how the functional topography of the LC changes over aging, and imply that spatial features of this organization are relevant markers of LC-related behavioral measures and psychopathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- locus coeruleus
- resting-state functional MRI
- connectivity
- cognition
- aging
- Human
- in-vivo visualization
- alzheimers-disease
- mri contrast
- human brains
- connectivity
- postmortem
- anxiety
- neuroanatomy
- depression
- arousal
- Life Sciences & Biomedicine - Other Topics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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eLife
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Vereb, D.
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Mijalkov, M.
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Canal-Garcia, A.
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Chang, Yu-Wei
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Gomez-Ruiz, Emil ...
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Gerboles, B. Z.
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visa fler...
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Kivipelto, M.
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Svenningsson, P.
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Zetterberg, Henr ...
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Volpe, Giovanni, ...
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Betts, M.
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Jacobs, H. I. L.
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Pereira, Joana B ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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eLife
- Av lärosätet
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Göteborgs universitet
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Lunds universitet
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Karolinska Institutet