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Connectome-based mo...
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
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- Vogel, Jacob W. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Corriveau-Lecavalier, N. (författare)
- Mayo Clinic Minnesota
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- Franzmeier, Nicolai, 1989 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Munich Cluster for Systems Neurology,University Hospital Munich,Sahlgrenska Academy
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- Pereira, Joana B. (författare)
- Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Brown, J. A. (författare)
- University of California, San Francisco
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- Maass, A. (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Botha, H. (författare)
- Mayo Clinic Minnesota
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- Seeley, W. W. (författare)
- University of California, San Francisco
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- Bassett, D. S. (författare)
- University of Pennsylvania,Santa Fe Institute
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- Jones, D. T. (författare)
- Mayo Clinic Minnesota
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- Ewers, M. (författare)
- University Hospital Munich
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Nature Reviews Neuroscience. - 1471-003X .- 1471-0048. ; 24:10, s. 620-639
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Abstract
Ämnesord
Stäng
- Neurodegenerative diseases are the most common cause of dementia. Although their underlying molecular pathologies have been identified, there is substantial heterogeneity in the patterns of progressive brain alterations across and within these diseases. Recent advances in neuroimaging methods have revealed that pathological proteins accumulate along specific macroscale brain networks, implicating the network architecture of the brain in the system-level pathophysiology of neurodegenerative diseases. However, the extent to which 'network-based neurodegeneration' applies across the wide range of neurodegenerative disorders remains unclear. Here, we discuss the state-of-the-art of neuroimaging-based connectomics for the mapping and prediction of neurodegenerative processes. We review findings supporting brain networks as passive conduits through which pathological proteins spread. As an alternative view, we also discuss complementary work suggesting that network alterations actively modulate the spreading of pathological proteins between connected brain regions. We conclude this Perspective by proposing an integrative framework in which connectome-based models can be advanced along three dimensions of innovation: incorporating parameters that modulate propagation behaviour on the basis of measurable biological features; building patient-tailored models that use individual-level information and allowing model parameters to interact dynamically over time. We discuss promises and pitfalls of these strategies for improving disease insights and moving towards precision medicine. Neurodegenerative diseases show idiosyncratic spatial patterns of progressive protein malformations in the brain. In this Perspective, Vogel et al. discuss the role of inter-regional connectivity in constraining and modulating the spread of pathological proteins and provide a framework for patient-tailored prognostics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- mild cognitive impairment
- variant frontotemporal dementia
- state
- functional connectivity
- cascading network failure
- amyloid-beta
- deposition
- alzheimers-disease
- tau pathology
- behavioral variant
- mouse
- model
- hippocampal hyperactivation
- Neurosciences & Neurology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Vogel, Jacob W.
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Corriveau-Lecava ...
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Franzmeier, Nico ...
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Pereira, Joana B ...
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Brown, J. A.
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Maass, A.
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visa fler...
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Botha, H.
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Seeley, W. W.
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Bassett, D. S.
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Jones, D. T.
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Ewers, M.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Nature Reviews N ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Lunds universitet