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FältnamnIndikatorerMetadata
00010291naa a2200961 4500
001oai:gup.ub.gu.se/331839
003SwePub
008240528s2023 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-108563
009oai:prod.swepub.kib.ki.se:153743742
009oai:DiVA.org:liu-198393
009oai:lup.lub.lu.se:48351675-aed2-43af-ac24-7553fcf3ae26
009oai:DiVA.org:uu-528598
0247 a https://gup.ub.gu.se/publication/3318392 URI
0247 a https://doi.org/10.1136/jnnp-2023-3318642 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1085632 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1537437422 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1983932 URI
0247 a https://lup.lub.lu.se/record/48351675-aed2-43af-ac24-7553fcf3ae262 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5285982 URI
040 a (SwePub)gud (SwePub)orud (SwePub)kid (SwePub)liud (SwePub)lud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Silfverberg, Thomasu Uppsala universitet,Uppsala University,Center for Clinical Research Dalarna,Centrum för klinisk forskning Dalarna,Hematologi4 aut0 (Swepub:uu)thosi392
2451 0a Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
264 1b BMJ Publishing Group Ltd,c 2023
500 a Funding Agencies|This study was presented as an abstract and oral presentation at the European Society for Blood and Marrow Transplantation 49th Annual Meeting, Paris, 23-26 April 2023.
520 a BackgroundA growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare.MethodsWe assessed 231 patients and the final analysis included 174 RRMS patients who were treated with aHSCT in Sweden before 1 January 2020. Efficacy was evaluated by performing a retrospective analysis of prospectively collected data from the Swedish MS registry. Procedure-related safety was assessed by analysing data from electronic patient records covering a period of 100 days following aHSCT.ResultsWith a median follow-up time of 5.5 (IQR: 3.4-7.5) years, the Kaplan-Meier estimate for no evidence of disease activity was 73% (95% CI 66% to 81%) at 5 years and 65% (95% CI 57% to 75%) at 10 years. Out of the 149 patients with baseline disability, 80 (54%) improved, 55 (37%) were stable and 14 (9%) deteriorated. The mean number of adverse events per patient was 1.7 (& PLUSMN;SD: 1.5) for grade 3 events and 0.06 (& PLUSMN;SD: 0.3) for grade 4 events. Febrile neutropenia was the most common adverse event, affecting 68% of patients. There was no treatment-related mortality.ConclusionsTreatment with aHSCT for RRMS is associated with freedom from disease activity in a majority of patients, with acceptable adverse events. This procedure should be considered a standard of care for patients with highly active RRMS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a multiple sclerosis
653 a haematology
653 a clinical neurology
653 a disease-modifying therapy
653 a alemtuzumab
653 a ms
653 a Neurosciences & Neurology
653 a Psychiatry
653 a Surgery
653 a CLINICAL NEUROLOGY
653 a CLINICAL NEUROLOGY
653 a HAEMATOLOGY
653 a MULTIPLE SCLEROSIS
7001 a Zjukovskaja, Christinau Uppsala universitet,Uppsala University,Experimentell neurologi4 aut0 (Swepub:uu)chrzh593
7001 a Ljungman, P.u Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ, Karolinska Comprehens Canc Ctr, Dept Cellular Therapy & Allogene Stem Cell Transpl, Hosp Huddinge, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Nahimi, Adjmalu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Restorative Parkinson Unit,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Neurol Rehabil Med Memory Disorders & Geriatr, Lund, Sweden.4 aut0 (Swepub:lu)ad7381na
7001 a Ahlstrand, Erik,d 1974-u Örebro University,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Medicine,Örebro Univ, Fac Med & Hlth, Dept Med, Örebro, Sweden.4 aut0 (Swepub:oru)ead
7001 a Dreimane, Artau Department of Hematology, Linköping University Hospital, Linköping, Sweden,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.4 aut0 (Swepub:liu)artdr13
7001 a Einarsdottir, Sigrunu University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Hematology and Coagulation, Sahlgrenska Sjukhuset, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Gothenburg, Sweden.,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xeinsi
7001 a Fagius, Janu Uppsala universitet,Uppsala University,Neurologi4 aut0 (Swepub:uu)janfagiu
7001 a Iacobaeus, E.u Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Hägglund, Hansu Uppsala universitet,Uppsala University,Karolinska University Hospital,Hematologi,Karolinska Univ, Karolinska Comprehens Canc Ctr, Dept Cellular Therapy & Allogene Stem Cell Transpl, Hosp Huddinge, Stockholm, Sweden.4 aut0 (Swepub:uu)hanha689
7001 a Lange, Niclas,d 1990-u Örebro University,Örebro Univ, Fac Med & Hlth, Dept Med, Örebro, Sweden.4 aut0 (Swepub:oru)nle
7001 a Lenhoff, Stigu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp Lund, Dept Hematol Oncol & Radiophys, Lund, Sweden.4 aut0 (Swepub:lu)med-slf
7001 a Lycke, Jan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden,Sahlgrens Acad, Dept Clin Neurosci, Inst Neurosci & Physiol, Gothenburg, Sweden.4 aut0 (Swepub:gu)xlycja
7001 a Mellergård, Johanu Linköping University,Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Linköping Univ, Dept Neurol, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.4 aut0 (Swepub:liu)johme15
7001 a Piehl, F.u Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Svenningsson, A.u Karolinska Institutet,Karolinska Inst, Dept Clin Sci, Institutionen Kliniska Vetenskaper, Danderyds Sjukhus, Stockholm, Sweden.;Karolinska Inst, Dept Neurol, Institutionen Kliniska Vetenskaper, Danderyds Sjukhus, Stockholm, Sweden.,Danderyd Hospital4 aut
7001 a Tolf, Andreasu Uppsala universitet,Uppsala University,Experimentell neurologi4 aut0 (Swepub:uu)andto164
7001 a Cherif, Honaru Uppsala universitet,Uppsala University,Hematologi4 aut0 (Swepub:uu)honch489
7001 a Carlson, Kristinau Uppsala universitet,Uppsala University,Hematologi4 aut0 (Swepub:uu)krica965
7001 a Burman, Joachim,d 1974-u Uppsala universitet,Uppsala University,Experimentell neurologi4 aut0 (Swepub:uu)joabu293
7102 a Uppsala Universityb Center for Clinical Research Dalarna4 org
7730 t Journal of Neurology Neurosurgery and Psychiatryd : BMJ Publishing Group Ltdx 0022-3050x 1468-330X
8564 u https://doi.org/10.1136/jnnp-2023-331864y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1803862/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1136/jnnp-2023-331864x freey FULLTEXT
8564 u https://uu.diva-portal.org/smash/get/diva2:1860705/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/331839
8564 8u https://doi.org/10.1136/jnnp-2023-331864
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108563
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:153743742
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198393
8564 8u https://lup.lub.lu.se/record/48351675-aed2-43af-ac24-7553fcf3ae26
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528598

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