Sökning: onr:"swepub:oai:gup.ub.gu.se/332253" >
Antipsychotics in t...
Antipsychotics in the maintenance phase for psychotic depression
-
- Al-Wandi, Ahmed, 1990- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Landén, Mikael, 1966 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Neuroscience and Physiology, the Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- Nordenskjöld, Axel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
-
Ingår i: Acta Psychiatrica Scandinavica. - : John Wiley & Sons. - 0001-690X .- 1600-0447. ; 149:1, s. 6-17
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://oru.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: This study aimed to associate antidepressants with versus without antipsychotics with readmission and suicide in patients with psychotic unipolar depression.Methods: Swedish national registers were used to identify inpatients with psychotic unipolar depression, treated 2007-2016. The participants collected antidepressants with or without antipsychotics from a pharmacy within 14 days after discharge and were followed up for 2 years. The primary outcome was hospital readmission due to any psychiatric disorder, suicide attempt, or completed suicide. Cox regression was used to analyze the data, which were adjusted for sex, age, prior admissions, comorbidity, electroconvulsive therapy, and other pharmacological treatments.Results: We identified 4391 patients, of which 2972 were in the antidepressant + antipsychotic combination therapy group, and 1419 were in the antidepressant monotherapy group. After 2 years, 42.3% and 36.6% of patients were readmitted or committed suicide in the combination therapy and monotherapy group, respectively. Monotherapy was significantly associated with a lower risk of reaching the outcome in the main analysis (hazard ratio = 0.86; 95% confidence interval: 0.77-0.95). The results went in the same direction in all sensitivity analyses.Conclusion: Our findings do not indicate any advantage of adding antipsychotics as adjunctive to antidepressants as maintenance treatment. Considering the wide use, known side effects, and the current lack of evidence supporting the benefit, further studies on the effect of antipsychotics in the maintenance phase of psychotic unipolar depression are urgently warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- antidepressants
- antipsychotics
- psychotic depression
- readmission
- relapse
- double-blind
- risperidone augmentation
- relapse prevention
- major
- depression
- follow-up
- placebo
- olanzapine
- combination
- monotherapy
- remission
- Psychiatry
- Antidepressants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas