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Early life exposure...
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Kirkeleit, JorunnDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway.
(författare)
Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/332360
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https://gup.ub.gu.se/publication/332360URI
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https://doi.org/10.1016/j.eclinm.2023.102339DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520088URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-218319URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20–68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991–2013 and 1997–2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers’ smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. Funding: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Riise, TrondDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
(författare)
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Wielscher, MathiasDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Dermatology, Medical University of Vienna, Vienna, Austria
(författare)
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Accordini, SimoneUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
(författare)
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Carsin, Anne ElieISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
(författare)
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Dratva, JulieInstitute of Health Sciences, School of Health Professions, Zürich University of Applied Sciences, Winterthur, Switzerland.; Medical Faculty, University of Basel, Basel, Switzerland.
(författare)
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Franklin, Karl A.Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)kafr0021
(författare)
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Garcia-Aymerich, JudithISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
(författare)
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Jarvis, DeborahNational Heart & Lung Institute, Imperial College, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College, London, UK.,National Heart & Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment and Health, Imperial College, London, United Kingdom
(författare)
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Leynaert, BenedicteUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
(författare)
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Lodge, Caroline J.Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.,Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
(författare)
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Real, Francisco GomezDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
(författare)
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Schlünssen, ViviDepartment of Public Health, Research Unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark.; The National Research Center for the Working Environment, Copenhagen, Denmark.
(författare)
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Corsico, Angelo GuidoDepartment of Medical Sciences and Infectious Diseases, Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
(författare)
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Heinrich, JoachimInstitute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Germany.
(författare)
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Holm, Mathias,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, Institute of Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xhomat
(författare)
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning,Arbets- och miljömedicin,Klinisk fysiologi,Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden(Swepub:uu)chrisjn
(författare)
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Benediktsdóttir, BryndisMedical Faculty, University of Iceland, Reykjavik, Iceland.
(författare)
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Jögi, RainLung Clinic, Tartu University Hospital, Tartu, Estonia(Swepub:uu)raijo735
(författare)
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Dharmage, Shyamali C.Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.,Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
(författare)
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Järvelin, Marjo RiittaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulun yliopisto, Finland; Unit of Primary Care, Oulu University Hospital, Oulu, Finland; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Middlesex, United Kingdom
(författare)
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Svanes, CecilieDepartment of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
(författare)
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Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway.; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.; Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway.Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:eClinicalMedicine: Elsevier662589-5370
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Kirkeleit, Jorun ...
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Riise, Trond
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Wielscher, Mathi ...
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Accordini, Simon ...
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Carsin, Anne Eli ...
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Dratva, Julie
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Franklin, Karl A ...
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Garcia-Aymerich, ...
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Jarvis, Deborah
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Leynaert, Benedi ...
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Lodge, Caroline ...
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Real, Francisco ...
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Schlünssen, Vivi
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Corsico, Angelo ...
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Heinrich, Joachi ...
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Holm, Mathias, 1 ...
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Janson, Christer
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Benediktsdóttir, ...
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Jögi, Rain
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Dharmage, Shyama ...
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Järvelin, Marjo ...
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Svanes, Cecilie
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