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Sökning: onr:"swepub:oai:gup.ub.gu.se/332702" > Prolonged Gastroint...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005008naa a2200601 4500
001oai:gup.ub.gu.se/332702
003SwePub
008240620s2024 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3327022 URI
0247 a https://doi.org/10.1016/j.cgh.2023.11.0092 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Elmunzer, B. Joseph4 aut
2451 0a Prolonged Gastrointestinal Manifestations After Recovery From COVID-19
264 1c 2024
520 a Background & Aims: Acute enteric infections are well known to result in long-term gastrointestinal (GI) disorders. Although COVID-19 is principally a respiratory illness, it demonstrates significant GI tropism, possibly predisposing to prolonged gut manifestations. We aimed to examine the long-term GI impact of hospitalization with COVID-19. Methods: Nested within a large-scale observational cohort study of patients hospitalized with COVID-19 across North America, we performed a follow-up survey of 530 survivors 12–18 months later to assess for persistent GI symptoms and their severity, and for the development of disorders of gut-brain interaction (DGBIs). Eligible patients were identified at the study site level and surveyed electronically. The survey instrument included the Rome IV Diagnostic Questionnaire for DGBI, a rating scale of 24 COVID-related symptoms, the Gastrointestinal Symptoms Rating Scale, and the Impact of Events–Revised trauma symptom questionnaire (a measure of posttraumatic stress associated with the illness experience). A regression analysis was performed to explore the factors associated with GI symptom severity at follow-up. Results: Of the 530 invited patients, 116 responded (52.6% females; mean age, 55.2 years), and 73 of those (60.3%) met criteria for 1 or more Rome IV DGBI at follow-up, higher than the prevalence in the US general population (P <. 0001). Among patients who experienced COVID-related GI symptoms during the index hospitalization (abdominal pain, nausea, vomiting, or diarrhea), 42.1% retained at least 1 of these symptoms at follow-up; in comparison, 89.8% of respondents retained any (GI or non-GI) COVID-related symptom. The number of moderate or severe GI symptoms experienced during the initial COVID-19 illness by self-report correlated with the development of DGBI and severity of GI symptoms at follow-up. Posttraumatic stress disorder (Impact of Events–Revised score ≥33) related to the COVID-19 illness experience was identified in 41.4% of respondents and those individuals had higher DGBI prevalence and GI symptom severity. Regression analysis revealed that higher psychological trauma score (Impact of Events–Revised) was the strongest predictor of GI symptom severity at follow-up. Conclusions: In this follow-up survey of patients 12–18 months after hospitalization with COVID-19, there was a high prevalence of DGBIs and persistent GI symptoms. Prolonged GI manifestations were associated with the severity of GI symptoms during hospitalization and with the degree of psychological trauma related to the illness experience.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a COVID-19
653 a Disorder of Gut-Brain Interaction
653 a Irritable Bowel Syndrome
653 a Long COVID
7001 a Palsson, Olafur S.4 aut
7001 a Forbes, Nauzer4 aut
7001 a Zakaria, Ali4 aut
7001 a Davis, Christian4 aut
7001 a Canakis, Andrew4 aut
7001 a Qayed, Emad4 aut
7001 a Bick, Benjamin4 aut
7001 a Pawa, Swati4 aut
7001 a Tierney, William M.4 aut
7001 a McLeod, Caroline G.4 aut
7001 a Taylor, Jason4 aut
7001 a Patel, Harsh4 aut
7001 a Mendelsohn, Robin B.4 aut
7001 a Bala, Gokul4 aut
7001 a Sloan, Ian4 aut
7001 a Merchant, Ambreen A.4 aut
7001 a Smith, Zachary L.4 aut
7001 a Sendzischew Shane, Morgan A.4 aut
7001 a Aroniadis, Olga C.4 aut
7001 a Ordiah, Collins O.4 aut
7001 a Ruddy, Johannah M.4 aut
7001 a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsimrm
7001 a Tack, Jan4 aut
7001 a Drossman, Douglas4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
7730 t Clinical Gastroenterology and Hepatologyg 22:5q 22:5x 1542-3565x 1542-7714
8564 8u https://gup.ub.gu.se/publication/332702
8564 8u https://doi.org/10.1016/j.cgh.2023.11.009

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