Sökning: onr:"swepub:oai:gup.ub.gu.se/332978" > Immunogenetics of l...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 08116nam a2201765 4500 | |
001 | oai:gup.ub.gu.se/332978 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:237461719 | |
024 | 7 | a https://gup.ub.gu.se/publication/3329782 URI |
024 | 7 | a https://doi.org/10.21203/rs.3.rs-3068352/v12 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2374617192 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a ovr2 swepub-publicationtype |
100 | 1 | a Herrera-Rivero, Marisol4 aut |
245 | 1 0 | a Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. |
264 | 1 | c 2023 |
520 | a The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi+Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1×10- 4 values, including HAS3, CNTNAP5 and NFIB. Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP's age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4, XKR4, NRXN1, NRG1/3 and GRK5. Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Gutiérrez-Fragoso, Karina4 aut |
700 | 1 | a Thalamuthu, Anbupalam4 aut |
700 | 1 | a Amare, Azmeraw T4 aut |
700 | 1 | a Adli, Mazda4 aut |
700 | 1 | a Akiyama, Kazufumi4 aut |
700 | 1 | a Akula, Nirmala4 aut |
700 | 1 | a Ardau, Raffaella4 aut |
700 | 1 | a Arias, Bárbara4 aut |
700 | 1 | a Aubry, Jean-Michel4 aut |
700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
700 | 1 | a Bellivier, Frank4 aut |
700 | 1 | a Benabarre, Antonio4 aut |
700 | 1 | a Bengesser, Susanne4 aut |
700 | 1 | a Abesh, Bhattacharjee4 aut |
700 | 1 | a Biernacka, Joanna4 aut |
700 | 1 | a Birner, Armin4 aut |
700 | 1 | a Cearns, Micah4 aut |
700 | 1 | a Cervantes, Pablo4 aut |
700 | 1 | a Chen, Hsi-Chung4 aut |
700 | 1 | a Chillotti, Caterinau Karolinska Institutet4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Clark, Scott4 aut |
700 | 1 | a Colom, Francesc4 aut |
700 | 1 | a Cruceanu, Cristiana4 aut |
700 | 1 | a Czerski, Piotr4 aut |
700 | 1 | a Dalkner, Nina4 aut |
700 | 1 | a Degenhardt, Franziska4 aut |
700 | 1 | a Del Zompo, Maria4 aut |
700 | 1 | a DePaulo, J Raymond4 aut |
700 | 1 | a Etain, Bruno4 aut |
700 | 1 | a Falkai, Peter4 aut |
700 | 1 | a Ferensztajn-Rochowiak, Ewa4 aut |
700 | 1 | a Forstner, Andreas J4 aut |
700 | 1 | a Frank, Josef4 aut |
700 | 1 | a Frisen, Louiseu Karolinska Institutet4 aut |
700 | 1 | a Frye, Mark4 aut |
700 | 1 | a Fullerton, Janice4 aut |
700 | 1 | a Gallo, Carla4 aut |
700 | 1 | a Gard, Sebastien4 aut |
700 | 1 | a Garnham, Julie4 aut |
700 | 1 | a Goes, Fernando4 aut |
700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
700 | 1 | a Grof, Paul4 aut |
700 | 1 | a Hashimoto, Ryota4 aut |
700 | 1 | a Hasler, Roland4 aut |
700 | 1 | a Hauser, Joanna4 aut |
700 | 1 | a Heilbronner, Urs4 aut |
700 | 1 | a Herms, Stefan4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a Hou, Liping4 aut |
700 | 1 | a Hsu, YiHsiang4 aut |
700 | 1 | a Jamain, Stéphane4 aut |
700 | 1 | a Jiménez, Esther4 aut |
700 | 1 | a Kahn, Jean-Pierre4 aut |
700 | 1 | a Kassem, Layla4 aut |
700 | 1 | a Kato, Tadafumi4 aut |
700 | 1 | a Kelsoe, John4 aut |
700 | 1 | a Kittel-Schneider, Sarah4 aut |
700 | 1 | a Kuo, Po-Hsiu4 aut |
700 | 1 | a Kurtz, Joachim4 aut |
700 | 1 | a Kusumi, Ichiro4 aut |
700 | 1 | a König, Barbara4 aut |
700 | 1 | a Laje, Gonzalo4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Lavebratt, Catharina4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Leckband, Susan4 aut |
700 | 1 | a Maj, Mariou Karolinska Institutet4 aut |
700 | 1 | a Manchia, Mirko4 aut |
700 | 1 | a Marie-Claire, Cynthia4 aut |
700 | 1 | a Martinsson, Linau Karolinska Institutet4 aut |
700 | 1 | a McCarthy, Michael4 aut |
700 | 1 | a McElroy, Susan L4 aut |
700 | 1 | a Millischer, Vincentu Karolinska Institutet4 aut |
700 | 1 | a Mitjans, Marina4 aut |
700 | 1 | a Mondimore, Francis4 aut |
700 | 1 | a Monteleone, Palmiero4 aut |
700 | 1 | a Nievergelt, Caroline4 aut |
700 | 1 | a Novak, Tomas4 aut |
700 | 1 | a Nöthen, Markus4 aut |
700 | 1 | a Odonovan, Claire4 aut |
700 | 1 | a Ozaki, Norio4 aut |
700 | 1 | a Papiol, Sergi4 aut |
700 | 1 | a Pfennig, Andrea4 aut |
700 | 1 | a Pisanu, Claudia4 aut |
700 | 1 | a Potash, James4 aut |
700 | 1 | a Reif, Andreas4 aut |
700 | 1 | a Reininghaus, Eva4 aut |
700 | 1 | a Richard-Lepouriel, Hélène4 aut |
700 | 1 | a Roberts, Gloria4 aut |
700 | 1 | a Rouleau, Guy4 aut |
700 | 1 | a Rybakowski, Janusz K4 aut |
700 | 1 | a Schalling, Martin4 aut |
700 | 1 | a Schofield, Peter4 aut |
700 | 1 | a Schubert, Klaus Oliver4 aut |
700 | 1 | a Schulte, Eva4 aut |
700 | 1 | a Schweizer, Barbara4 aut |
700 | 1 | a Severino, Giovanni4 aut |
700 | 1 | a Shekhtman, Tatyana4 aut |
700 | 1 | a Shilling, Paul4 aut |
700 | 1 | a Shimoda, Kazutaka4 aut |
700 | 1 | a Simhandl, Christian4 aut |
700 | 1 | a Slaney, Claire4 aut |
700 | 1 | a Squassina, Alessio4 aut |
700 | 1 | a Stamm, Thomas4 aut |
700 | 1 | a Stopkova, Pavla4 aut |
700 | 1 | a Streit, Fabian4 aut |
700 | 1 | a Ayele, Fasil4 aut |
700 | 1 | a Tortorella, Alfonso4 aut |
700 | 1 | a Turecki, Gustavo4 aut |
700 | 1 | a Veeh, Julia4 aut |
700 | 1 | a Vieta, Eduard4 aut |
700 | 1 | a Viswanath, Biju4 aut |
700 | 1 | a Witt, Stephanie4 aut |
700 | 1 | a Zandi, Peter4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Bauer, Michael4 aut |
700 | 1 | a McMahon, Francis4 aut |
700 | 1 | a Mitchell, Philip4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a Schulze, Thomas4 aut |
700 | 1 | a Baune, Bernhard4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Research square |
856 | 4 8 | u https://gup.ub.gu.se/publication/332978 |
856 | 4 8 | u https://doi.org/10.21203/rs.3.rs-3068352/v1 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:237461719 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.