Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: onr:"swepub:oai:gup.ub.gu.se/332978" > Immunogenetics of l...

1 av 1
Föregående post
Nästa post
Till träfflistan

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		08116nam a2201765 4500
001		oai:gup.ub.gu.se/332978
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237461719
024	7	a https://gup.ub.gu.se/publication/3329782 URI
024	7	a https://doi.org/10.21203/rs.3.rs-3068352/v12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2374617192 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Herrera-Rivero, Marisol4 aut
245	1 0	a Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.
264	1	c 2023
520		a The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi+Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1×10- 4 values, including HAS3, CNTNAP5 and NFIB. Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP's age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4, XKR4, NRXN1, NRG1/3 and GRK5. Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Gutiérrez-Fragoso, Karina4 aut
700	1	a Thalamuthu, Anbupalam4 aut
700	1	a Amare, Azmeraw T4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Abesh, Bhattacharjee4 aut
700	1	a Biernacka, Joanna4 aut
700	1	a Birner, Armin4 aut
700	1	a Cearns, Micah4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Clark, Scott4 aut
700	1	a Colom, Francesc4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Etain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frank, Josef4 aut
700	1	a Frisen, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark4 aut
700	1	a Fullerton, Janice4 aut
700	1	a Gallo, Carla4 aut
700	1	a Gard, Sebastien4 aut
700	1	a Garnham, Julie4 aut
700	1	a Goes, Fernando4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hasler, Roland4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Hou, Liping4 aut
700	1	a Hsu, YiHsiang4 aut
700	1	a Jamain, Stéphane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kurtz, Joachim4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a König, Barbara4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan4 aut
700	1	a Maj, Mariou Karolinska Institutet4 aut
700	1	a Manchia, Mirko4 aut
700	1	a Marie-Claire, Cynthia4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael4 aut
700	1	a McElroy, Susan L4 aut
700	1	a Millischer, Vincentu Karolinska Institutet4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline4 aut
700	1	a Novak, Tomas4 aut
700	1	a Nöthen, Markus4 aut
700	1	a Odonovan, Claire4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Pisanu, Claudia4 aut
700	1	a Potash, James4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Richard-Lepouriel, Hélène4 aut
700	1	a Roberts, Gloria4 aut
700	1	a Rouleau, Guy4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Schulte, Eva4 aut
700	1	a Schweizer, Barbara4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Shilling, Paul4 aut
700	1	a Shimoda, Kazutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Streit, Fabian4 aut
700	1	a Ayele, Fasil4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Veeh, Julia4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Viswanath, Biju4 aut
700	1	a Witt, Stephanie4 aut
700	1	a Zandi, Peter4 aut
700	1	a Alda, Martin4 aut
700	1	a Bauer, Michael4 aut
700	1	a McMahon, Francis4 aut
700	1	a Mitchell, Philip4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Schulze, Thomas4 aut
700	1	a Baune, Bernhard4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Research square
856	4 8	u https://gup.ub.gu.se/publication/332978
856	4 8	u https://doi.org/10.21203/rs.3.rs-3068352/v1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237461719

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Herrera-Rivero, ...; Gutiérrez-Fragos ...; Thalamuthu, Anbu ...; Amare, Azmeraw T; Adli, Mazda; Akiyama, Kazufum ...; visa fler...; Akula, Nirmala; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Abesh, Bhattacha ...; Biernacka, Joann ...; Birner, Armin; Cearns, Micah; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Clark, Scott; Colom, Francesc; Cruceanu, Cristi ...; Czerski, Piotr; Dalkner, Nina; Degenhardt, Fran ...; Del Zompo, Maria; DePaulo, J Raymo ...; Etain, Bruno; Falkai, Peter; Ferensztajn-Roch ...; Forstner, Andrea ...; Frank, Josef; Frisen, Louise; Frye, Mark; Fullerton, Janic ...; Gallo, Carla; Gard, Sebastien; Garnham, Julie; Goes, Fernando; Grigoroiu-Serban ...; Grof, Paul; Hashimoto, Ryota; Hasler, Roland; Hauser, Joanna; Heilbronner, Urs; Herms, Stefan; Hoffmann, Per; Hou, Liping; Hsu, YiHsiang; Jamain, Stéphane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kato, Tadafumi; Kelsoe, John; Kittel-Schneider ...; Kuo, Po-Hsiu; Kurtz, Joachim; Kusumi, Ichiro; König, Barbara; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan; Maj, Mario; Manchia, Mirko; Marie-Claire, Cy ...; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; Millischer, Vinc ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Novak, Tomas; Nöthen, Markus; Odonovan, Claire; Ozaki, Norio; Papiol, Sergi; Pfennig, Andrea; Pisanu, Claudia; Potash, James; Reif, Andreas; Reininghaus, Eva; Richard-Lepourie ...; Roberts, Gloria; Rouleau, Guy; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter; Schubert, Klaus ...; Schulte, Eva; Schweizer, Barba ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul; Shimoda, Kazutak ...; Simhandl, Christ ...; Slaney, Claire; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Streit, Fabian; Ayele, Fasil; Tortorella, Alfo ...; Turecki, Gustavo; Veeh, Julia; Vieta, Eduard; Viswanath, Biju; Witt, Stephanie; Zandi, Peter; Alda, Martin; Bauer, Michael; McMahon, Francis; Mitchell, Philip; Rietschel, Marce ...; Schulze, Thomas; Baune, Bernhard; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Research square

Av lärosätet: Göteborgs universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se