Sökning: onr:"swepub:oai:gup.ub.gu.se/332986" > Lithium Response in...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07558nam a2201825 4500 | |
001 | oai:gup.ub.gu.se/332986 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:237886563 | |
024 | 7 | a https://gup.ub.gu.se/publication/3329862 URI |
024 | 7 | a https://doi.org/10.21203/rs.3.rs-3258813/v12 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2378865632 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a ovr2 swepub-publicationtype |
100 | 1 | a Kelsoe, John4 aut |
245 | 1 0 | a Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study. |
264 | 1 | c 2023 |
520 | a Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Ou, Anna4 aut |
700 | 1 | a Rosenthal, Sara4 aut |
700 | 1 | a Adli, Mazda4 aut |
700 | 1 | a Akiyama, Kazufumi4 aut |
700 | 1 | a Akula, Nirmala4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Amare, Azmeraw T4 aut |
700 | 1 | a Ardau, Raffaella4 aut |
700 | 1 | a Arias, Bárbara4 aut |
700 | 1 | a Aubry, Jean-Michel4 aut |
700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
700 | 1 | a Banzato, Claudio4 aut |
700 | 1 | a Bauer, Michael4 aut |
700 | 1 | a Baune, Bernhard4 aut |
700 | 1 | a Bellivier, Frank4 aut |
700 | 1 | a Benabarre, Antonio4 aut |
700 | 1 | a Bengesser, Susanne4 aut |
700 | 1 | a Abesh, Bhattacharjee4 aut |
700 | 1 | a Biernacka, Joanna4 aut |
700 | 1 | a Bui, Elise4 aut |
700 | 1 | a Cervantes, Pablo4 aut |
700 | 1 | a Chen, Guo-Bo4 aut |
700 | 1 | a Chen, Hsi-Chung4 aut |
700 | 1 | a Chillotti, Caterinau Karolinska Institutet4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Clark, Scott4 aut |
700 | 1 | a Colom, Francesc4 aut |
700 | 1 | a Cousins, David4 aut |
700 | 1 | a Cruceanu, Cristiana4 aut |
700 | 1 | a Czerski, Piotr4 aut |
700 | 1 | a Dantas, Clarissa4 aut |
700 | 1 | a Dayer, Alexandre4 aut |
700 | 1 | a Degenhardt, Franziska4 aut |
700 | 1 | a DePaulo, J Raymond4 aut |
700 | 1 | a Etain, Bruno4 aut |
700 | 1 | a Falkai, Peter4 aut |
700 | 1 | a Fellendorf, Frederike4 aut |
700 | 1 | a Ferensztajn-Rochowiak, Ewa4 aut |
700 | 1 | a Forstner, Andreas J4 aut |
700 | 1 | a Frisen, Louiseu Karolinska Institutet4 aut |
700 | 1 | a Frye, Mark4 aut |
700 | 1 | a Fullerton, Janice4 aut |
700 | 1 | a Gard, Sebastien4 aut |
700 | 1 | a Garnham, Julie4 aut |
700 | 1 | a Goes, Fernando4 aut |
700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
700 | 1 | a Grof, Paul4 aut |
700 | 1 | a Gruber, Oliver4 aut |
700 | 1 | a Hashimoto, Ryota4 aut |
700 | 1 | a Hauser, Joanna4 aut |
700 | 1 | a Heilbronner, Urs4 aut |
700 | 1 | a Herms, Stefan4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a Hofmann, Andrea4 aut |
700 | 1 | a Hou, Liping4 aut |
700 | 1 | a Jamain, Stéphane4 aut |
700 | 1 | a Jiménez, Esther4 aut |
700 | 1 | a Kahn, Jean-Pierre4 aut |
700 | 1 | a Kassem, Layla4 aut |
700 | 1 | a Kato, Tadafumi4 aut |
700 | 1 | a Kittel-Schneider, Sarah4 aut |
700 | 1 | a König, Barbara4 aut |
700 | 1 | a Kuo, Po-Hsiu4 aut |
700 | 1 | a Kusumi, Ichiro4 aut |
700 | 1 | a Dalkner, Nina4 aut |
700 | 1 | a Laje, Gonzalo4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Lavebratt, Catharina4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Leckband, Susan4 aut |
700 | 1 | a Jaramillo, Carlos López4 aut |
700 | 1 | a MacQueen, Glenda4 aut |
700 | 1 | a Maj, Mariou Karolinska Institutet4 aut |
700 | 1 | a Manchia, Mirko4 aut |
700 | 1 | a Marie-Claire, Cynthia4 aut |
700 | 1 | a Martinsson, Linau Karolinska Institutet4 aut |
700 | 1 | a Mattheisen, Manuel4 aut |
700 | 1 | a McCarthy, Michael4 aut |
700 | 1 | a McElroy, Susan4 aut |
700 | 1 | a McMahon, Francis4 aut |
700 | 1 | a Mitchell, Philip4 aut |
700 | 1 | a Mitjans, Marina4 aut |
700 | 1 | a Mondimore, Francis4 aut |
700 | 1 | a Monteleone, Palmiero4 aut |
700 | 1 | a Nievergelt, Caroline4 aut |
700 | 1 | a Nöthen, Markus4 aut |
700 | 1 | a Novak, Tomas4 aut |
700 | 1 | a Osby, Urban4 aut |
700 | 1 | a Ozaki, Norio4 aut |
700 | 1 | a Papiol, Sergi4 aut |
700 | 1 | a Perlis, Roy4 aut |
700 | 1 | a Pfennig, Andrea4 aut |
700 | 1 | a Potash, James4 aut |
700 | 1 | a Reich-Erkelenz, Daniela4 aut |
700 | 1 | a Reif, Andreas4 aut |
700 | 1 | a Reininghaus, Eva4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a Rouleau, Guy4 aut |
700 | 1 | a Rybakowski, Janusz K4 aut |
700 | 1 | a Schalling, Martin4 aut |
700 | 1 | a Schofield, Peter4 aut |
700 | 1 | a Schubert, Klaus Oliver4 aut |
700 | 1 | a Schulze, Thomas4 aut |
700 | 1 | a Schweizer, Barbara4 aut |
700 | 1 | a Seemüller, Florian4 aut |
700 | 1 | a Severino, Giovanni4 aut |
700 | 1 | a Shekhtman, Tatyana4 aut |
700 | 1 | a Shilling, Paul4 aut |
700 | 1 | a Shimoda, Kazutaka4 aut |
700 | 1 | a Simhandl, Christian4 aut |
700 | 1 | a Slaney, Claire4 aut |
700 | 1 | a Squassina, Alessio4 aut |
700 | 1 | a Stamm, Thomas4 aut |
700 | 1 | a Stopkova, Pavla4 aut |
700 | 1 | a Tighe, Sarah4 aut |
700 | 1 | a Tortorella, Alfonso4 aut |
700 | 1 | a Turecki, Gustavo4 aut |
700 | 1 | a Vieta, Eduard4 aut |
700 | 1 | a Volkert, Julia4 aut |
700 | 1 | a Witt, Stephanie4 aut |
700 | 1 | a Wray, Naomi4 aut |
700 | 1 | a Wright, Adam4 aut |
700 | 1 | a Young, Trevor4 aut |
700 | 1 | a Zandi, Peter4 aut |
700 | 1 | a Zompo, Maria Del4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Research square |
856 | 4 8 | u https://gup.ub.gu.se/publication/332986 |
856 | 4 8 | u https://doi.org/10.21203/rs.3.rs-3258813/v1 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:237886563 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.