Sökning: onr:"swepub:oai:gup.ub.gu.se/333227" >
Antibody and B-cell...
Antibody and B-cell Immune Responses Against Bordetella Pertussis Following Infection and Immunization
-
Abu-Raya, Bahaa (författare)
-
Esser, Mirjam J. (författare)
-
Nakabembe, Eve (författare)
-
visa fler...
-
Reiné, Jesús (författare)
-
Amaral, Kyle (författare)
-
Diks, Annieck M. (författare)
-
Imede, Esther (författare)
-
Way, Sing Sing (författare)
-
- Harandi, Ali M, 1968 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
Gorringe, Andrew (författare)
-
Le Doare, Kirsty (författare)
-
Halperin, Scott A. (författare)
-
Berkowska, Magdalena A. (författare)
-
Sadarangani, Manish (författare)
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Journal of Molecular Biology. - 0022-2836 .- 1089-8638. ; 435:24
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Neither immunization nor recovery from natural infection provides life-long protection against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an acellular pertussis (aP) vaccine, mutations in B. pertussis strains, and better diagnostic techniques, contribute to resurgence of number of cases especially in young infants. Development of new immunization strategies relies on a comprehensive understanding of immune system responses to infection and immunization and how triggering these immune components would ensure protective immunity. In this review, we assess how B cells, and their secretory products, antibodies, respond to B. pertussis infection, current and novel vaccines and highlight similarities and differences in these responses. We first focus on antibody-mediated immunity. We discuss antibody (sub)classes, elaborate on antibody avidity, ability to neutralize pertussis toxin, and summarize different effector functions, i.e. ability to activate complement, promote phagocytosis and activate NK cells. We then discuss challenges and opportunities in studying B-cell immunity. We highlight shared and unique aspects of B-cell and plasma cell responses to infection and immunization, and discuss how responses to novel immunization strategies better resemble those triggered by a natural infection (i.e., by triggering responses in mucosa and production of IgA). With this comprehensive review, we aim to shed some new light on the role of B cells and antibodies in the pertussis immunity to guide new vaccine development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- B-cell immunity
- humoral immunity
- infection
- pertussis
- vaccination
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Abu-Raya, Bahaa
-
Esser, Mirjam J.
-
Nakabembe, Eve
-
Reiné, Jesús
-
Amaral, Kyle
-
Diks, Annieck M.
-
visa fler...
-
Imede, Esther
-
Way, Sing Sing
-
Harandi, Ali M, ...
-
Gorringe, Andrew
-
Le Doare, Kirsty
-
Halperin, Scott ...
-
Berkowska, Magda ...
-
Sadarangani, Man ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Journal of Molec ...
- Av lärosätet
-
Göteborgs universitet