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Early steps in the ...
Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits
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- Jung, Sung-Jun, 1987 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Sridhara, Sagar, 1989 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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- Ott, Martin, 1974 (författare)
- Stockholms universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Institutionen för biokemi och biofysik,University of Gothenburg, Sweden
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: IUBMB LIFE. - 1521-6543 .- 1521-6551. ; 76:3, s. 125-139
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The complexes mediating oxidative phosphorylation (OXPHOS) in the inner mitochondrial membrane consist of proteins encoded in the nuclear or the mitochondrial DNA. The mitochondrially encoded membrane proteins (mito-MPs) represent the catalytic core of these complexes and follow complicated pathways for biogenesis. Owing to their overall hydrophobicity, mito-MPs are co-translationally inserted into the inner membrane by the Oxa1 insertase. After insertion, OXPHOS biogenesis factors mediate the assembly of mito-MPs into complexes and participate in the regulation of mitochondrial translation, while protein quality control factors recognize and degrade faulty or excess proteins. This review summarizes the current understanding of these early steps occurring during the assembly of mito-MPs by concentrating on results obtained in the model organism baker's yeast.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- eukaryotic gene expression
- mitochondria
- protein folding
- protein synthesis
- eukaryotic gene expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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