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Sökning: onr:"swepub:oai:gup.ub.gu.se/335493" > Individual regional...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004988naa a2200781 4500
001oai:gup.ub.gu.se/335493
003SwePub
008240528s2023 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3354932 URI
0247 a https://doi.org/10.1038/s41380-023-02188-82 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Finze, Anika4 aut
2451 0a Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies
264 1c 2023
520 a & beta;-amyloid (A & beta;) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients with AD and primary tauopathies and 10 healthy controls that underwent TSPO-, A & beta;-, tau-, and perfusion-surrogate-PET, as well as structural MRI. Z-score deviations for 246 brain regions were calculated and biomarker contributions of A & beta; (A), tau (T), perfusion (N1), and gray matter atrophy (N2) to microglial activation (TSPO, I) were calculated for each individual subject. Individual ATN-related microglial activation was correlated with clinical performance and CSF soluble TREM2 (sTREM2) concentrations. In typical and atypical AD, regional tau was stronger and more frequently associated with microglial activation when compared to regional A & beta; (AD: & beta;(T) = 0.412 & PLUSMN; 0.196 vs. & beta;(A) = 0.142 & PLUSMN; 0.123, p < 0.001; AD-CBS: & beta;(T) = 0.385 & PLUSMN; 0.176 vs. & beta;(A) = 0.131 & PLUSMN; 0.186, p = 0.031). The strong association between regional tau and microglia reproduced well in primary tauopathies (& beta;(T) = 0.418 & PLUSMN; 0.154). Stronger individual associations between tau and microglial activation were associated with poorer clinical performance. In patients with 4RT, sTREM2 levels showed a positive association with tau-related microglial activation. Tau pathology has strong regional associations with microglial activation in primary and secondary tauopathies. Tau and A & beta; related microglial response indices may serve as a two-dimensional in vivo assessment of neuroinflammation in neurodegenerative diseases.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
7001 a Biechele, Gloria4 aut
7001 a Rauchmann, Boris-Stephan4 aut
7001 a Franzmeier, Nicolai,d 1989u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xfnico
7001 a Palleis, Carla4 aut
7001 a Katzdobler, Sabrina4 aut
7001 a Weidinger, Endy4 aut
7001 a Guersel, Selim4 aut
7001 a Schuster, Sebastian4 aut
7001 a Harris, Stefanie4 aut
7001 a Schmitt, Julia4 aut
7001 a Beyer, Leonie4 aut
7001 a Gnoerich, Johannes4 aut
7001 a Lindner, Simon4 aut
7001 a Albert, Nathalie L.4 aut
7001 a Wetzel, Christian H.4 aut
7001 a Rupprecht, Rainer4 aut
7001 a Rominger, Axel4 aut
7001 a Danek, Adrian4 aut
7001 a Burow, Lena4 aut
7001 a Kurz, Carolin4 aut
7001 a Tato, Maia4 aut
7001 a Utecht, Julia4 aut
7001 a Papazov, Boris4 aut
7001 a Zaganjori, Mirlind4 aut
7001 a Trappmann, Lena-Katharina4 aut
7001 a Goldhardt, Oliver4 aut
7001 a Grimmer, Timo4 aut
7001 a Haeckert, Jan4 aut
7001 a Janowitz, Daniel4 aut
7001 a Buerger, Katharina4 aut
7001 a Keeser, Daniel4 aut
7001 a Stoecklein, Sophia4 aut
7001 a Dietrich, Olaf4 aut
7001 a Morenas-Rodriguez, Estrella4 aut
7001 a Barthel, Henryk4 aut
7001 a Sabri, Osama4 aut
7001 a Bartenstein, Peter4 aut
7001 a Simons, Mikael4 aut
7001 a Haass, Christian4 aut
7001 a Hoeglinger, Gunter U.4 aut
7001 a Levin, Johannes4 aut
7001 a Perneczky, Robert4 aut
7001 a Brendel, Matthias4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t MOLECULAR PSYCHIATRYg 28:10, s. 4438-4450q 28:10<4438-4450x 1359-4184x 1476-5578
8564 8u https://gup.ub.gu.se/publication/335493
8564 8u https://doi.org/10.1038/s41380-023-02188-8

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