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Outcome Measures fo...
Outcome Measures for Disease-Modifying Trials in Parkinson's Disease: Consensus Paper by the EJS ACT-PD Multi-Arm Multi-Stage Trial Initiative
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Gonzalez-Robles, Cristina (författare)
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Weil, Rimona S. (författare)
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van Wamelen, Daniel (författare)
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visa fler...
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Bartlett, Michele (författare)
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Burnell, Matthew (författare)
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Clarke, Caroline S. (författare)
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Hu, Michele T. (författare)
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Huxford, Brook (författare)
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Jha, Ashwani (författare)
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Lambert, Christian (författare)
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Lawton, Michael (författare)
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Mills, Georgia (författare)
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Noyce, Alastair (författare)
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Piccini, Paola (författare)
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Pushparatnam, Kuhan (författare)
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Rochester, Lynn (författare)
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Siu, Carroll (författare)
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Williams-Gray, Caroline H. (författare)
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Zeissler, Marie-Louise (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Carroll, Camille B. (författare)
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Foltynie, Thomas (författare)
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Schrag, Anette (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: JOURNAL OF PARKINSONS DISEASE. - 1877-7171 .- 1877-718X. ; 13:6, s. 1013-1035
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Background: Multi-arm, multi-stage (MAMS) platform trials can accelerate the identification of disease-modifying treatments for Parkinson's disease (PD) but there is no current consensus on the optimal outcome measures (OM) for this approach. Objective: To provide an up-to-date inventory of OM for disease-modifying PD trials, and a framework for future selection of OM for such trials. Methods: As part of the Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT-PD) initiative, an expert group with Patient and Public Involvement and Engagement (PPIE) representatives' input reviewed and evaluated available evidence on OM for potential use in trials to delay progression of PD. Each OM was ranked based on aspects such as validity, sensitivity to change, participant burden and practicality for a multi-site trial. Review of evidence and expert opinion led to the present inventory. Results: An extensive inventory ofOMwas created, divided into: general, motor and non-motor scales, diaries and fluctuation questionnaires, cognitive, disability and health-related quality of life, capability, quantitative motor, wearable and digital, combined, resource use, imaging and wet biomarkers, and milestone-based. A framework for evaluation of OM is presented to update the inventory in the future. PPIE input highlighted the need for OM which reflect their experience of disease progression and are applicable to diverse populations and disease stages. Conclusion: We present a range of OM, classified according to a transparent framework, to aid selection of OM for disease-modifying PD trials, whilst allowing for inclusion or re-classification of relevant OM as new evidence emerges.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Parkinson's disease
- neuroprotection
- outcome measures
- biomarkers
- clinical trials
- consensus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gonzalez-Robles, ...
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Weil, Rimona S.
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van Wamelen, Dan ...
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Bartlett, Michel ...
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Burnell, Matthew
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Clarke, Caroline ...
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visa fler...
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Hu, Michele T.
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Huxford, Brook
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Jha, Ashwani
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Lambert, Christi ...
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Lawton, Michael
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Mills, Georgia
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Noyce, Alastair
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Piccini, Paola
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Pushparatnam, Ku ...
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Rochester, Lynn
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Siu, Carroll
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Williams-Gray, C ...
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Zeissler, Marie- ...
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Zetterberg, Henr ...
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Carroll, Camille ...
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Foltynie, Thomas
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Schrag, Anette
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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JOURNAL OF PARKI ...
- Av lärosätet
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Göteborgs universitet