Sökning: onr:"swepub:oai:gup.ub.gu.se/335664" > Outcomes by sex in ...
Fältnamn | Indikatorer | Metadata |
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000 | 03578naa a2200373 4500 | |
001 | oai:gup.ub.gu.se/335664 | |
003 | SwePub | |
008 | 240813s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3356642 URI |
024 | 7 | a https://doi.org/10.4244/EIJ-D-24-000112 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gaudino, Mario4 aut |
245 | 1 0 | a Outcomes by sex in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial. |
264 | 1 | c 2024 |
520 | a In the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial, among participants with stable coronary artery disease, the risk of cardiac events was similar between an invasive (INV) strategy of angiography and coronary revascularisation and a conservative (CON) strategy of initial medical therapy alone. Outcomes according to participant sex were not reported.We aimed to analyse the outcomes of ISCHEMIA by participant sex.We evaluated 1) the association between participant sex and the likelihood of undergoing revascularisation for participants randomised to the INV arm; 2) the risk of the ISCHEMIA primary composite outcome (cardiovascular death, any myocardial infarction [MI] or rehospitalisation for unstable angina, heart failure or resuscitated cardiac arrest) by participant sex; and 3) the contribution of the individual primary outcome components to the composite outcome by participant sex.Of 5,179 randomised participants, 1,168 (22.6%) were women. Female sex was independently associated with a lower likelihood of revascularisation when assigned to the INV arm (adjusted odds ratio 0.75, 95% confidence interval [CI]: 0.57-0.99; p=0.04). The INV versus CON effect on the primary composite outcome was similar between sexes (women: hazard ratio [HR] 0.96, 95% CI: 0.70-1.33; men: HR 0.90, 95% CI: 0.76-1.07; pinteraction=0.71). The contribution of the individual components to the composite outcome was similar between sexes except for procedural MI, which was significantly lower in women (9/151 [5.9%]) than men (67/519 [12.9%]; p=0.01).In ISCHEMIA, women assigned to the INV arm were less likely to undergo revascularisation than men. The effect of an INV versus CON strategy was consistent by sex, but women had a significantly lower contribution of procedural MI to the primary outcome. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Alexander, John H4 aut |
700 | 1 | a Sandner, Sigrid4 aut |
700 | 1 | a Harik, Lamia4 aut |
700 | 1 | a Kim, Jessica4 aut |
700 | 1 | a Stone, Gregg W4 aut |
700 | 1 | a Rahouma, Mohamed4 aut |
700 | 1 | a O'Gara, Patrick4 aut |
700 | 1 | a Bhatt, Deepak L4 aut |
700 | 1 | a Redfors, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xredbj |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t EuroInterventiong 20:9, s. 551-560q 20:9<551-560x 1774-024Xx 1969-6213 |
856 | 4 8 | u https://gup.ub.gu.se/publication/335664 |
856 | 4 8 | u https://doi.org/10.4244/EIJ-D-24-00011 |
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