Sökning: onr:"swepub:oai:gup.ub.gu.se/336116" > Plasma p-tau181 as ...
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000 | 09112naa a2201453 4500 | |
001 | oai:gup.ub.gu.se/336116 | |
003 | SwePub | |
008 | 240910s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3361162 URI |
024 | 7 | a https://doi.org/10.1016/S2666-7568(23)00255-62 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Coley, Nicola4 aut |
245 | 1 0 | a Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial |
264 | 1 | c 2024 |
520 | a Background: It is unknown whether multidomain interventions, which might preserve late-life cognition, affect Alzheimer's disease pathology. Previous studies measured cerebrospinal fluid and imaging Alzheimer's disease biomarkers in small subsamples of multidomain trial participants. Newly developed assays enable the measurement of blood-based Alzheimer's disease biomarkers in larger samples. We aimed to assess whether plasma tau phosphorylated at threonine 181 (p-tau181) was able to detect or predict 3-year multidomain intervention effects. Methods: This is a secondary analysis of the randomised, controlled, Multidomain Alzheimer Prevention Trial (MAPT) testing a 3-year multidomain intervention, omega-3 fatty acid supplementation, or both versus placebo, in individuals aged 70 years and older in 13 memory centres in France and Monaco. Plasma p-tau181 was measured in stored blood samples in a subsample of 527 participants on an intention-to-treat basis. Changes in cognitive score were calculated as a composite measure using the average of Z scores for the following tests: Mini Mental State Examination orientation items, Free and Cued Selective Reminding Test (sum of free and total recall scores), category fluency, and Digit Symbol Substitution Test. Intervention effects on 3-year change in p-tau181 concentration were estimated by use of a linear mixed model with centre-specific random intercepts. Findings: Recruitment took place between May 30, 2008, and Feb 24, 2011. Median baseline plasma p-tau181 was 8·8 pg/mL (IQR 6·7–11·9) in the total sample, and significantly higher in older individuals, men, APOE ε4 carriers, and participants with renal dysfunction or a positive PET amyloid scan. During 3-year follow-up, individuals with raised baseline p-tau181 underwent greater cognitive decline (eg, mean difference in 3-year change on the composite cognitive score between control group participants with normal and abnormal baseline levels of p-tau was −0·34 [effect size −0·52; 95% CI −0·61 to 0·07] in the fully adjusted model using a 12·4 pg/mL cutoff for abnormal baseline p-tau181), but there were no intervention effects on change in p-tau181 either in this subgroup or the total population, and no effect on cognitive change in individuals with raised baseline p-tau181 (eg, in the fully adjusted model using the 12·4 pg/mL cutoff for p-tau181 abnormality, the mean difference [95% CI] in this subgroup in 3-year decline on the composite cognitive score between the control group and the multidomain + omega-3 group, the omega-3 group, and the multidomain intervention group, was, respectively: 0·13 [−0·21 to 0·47], 0·03 [−0·30 to 0·36], and 0·10 [−0·26 to 0·46]). Surprisingly, individuals with raised baseline p-tau181 showed a decrease in p-tau181 during follow-up (eg, unadjusted mean [95% CI] 3-year change was −3·01 pg/mL (−4·45 to −1·56) in control group subjects with abnormal baseline p-tau181 [using the 12·4 pg/mL abnormal p-tau cutoff]). Interpretation: Our results support the utility of p-tau181 as a prognostic biomarker, but it did not predict or detect intervention effects in this study. Further investigation of its usefulness as a prevention trial outcome measure is required. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Cantet, Christelle4 aut |
700 | 1 | a Guyonnet, Sophie4 aut |
700 | 1 | a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn |
700 | 1 | a Vellas, Bruno4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Andrieu, Sandrine4 aut |
700 | 1 | a Carrié, Isabelle4 aut |
700 | 1 | a Brigitte, Lauréane4 aut |
700 | 1 | a Faisant, Catherine4 aut |
700 | 1 | a Lala, Françoise4 aut |
700 | 1 | a Delrieu, Julien4 aut |
700 | 1 | a Villars, Hélène4 aut |
700 | 1 | a Combrouze, Emeline4 aut |
700 | 1 | a Badufle, Carole4 aut |
700 | 1 | a Zueras, Audrey4 aut |
700 | 1 | a Morin, Christophe4 aut |
700 | 1 | a Abellan Van Kan, Gabor4 aut |
700 | 1 | a Dupuy, Charlotte4 aut |
700 | 1 | a Rolland, Yves4 aut |
700 | 1 | a Caillaud, Céline4 aut |
700 | 1 | a Ousset, Pierre Jean4 aut |
700 | 1 | a Willis, Sherry4 aut |
700 | 1 | a Belleville, Sylvie4 aut |
700 | 1 | a Gilbert, Brigitte4 aut |
700 | 1 | a Fontaine, Francine4 aut |
700 | 1 | a Dartigues, Jean François4 aut |
700 | 1 | a Marcet, Isabelle4 aut |
700 | 1 | a Delva, Fleur4 aut |
700 | 1 | a Foubert, Alexandra4 aut |
700 | 1 | a Cerda, Sandrine4 aut |
700 | 1 | a Cuffi, Marie Noëlle4 aut |
700 | 1 | a Costes, Corinne4 aut |
700 | 1 | a Rouaud, Olivier4 aut |
700 | 1 | a Manckoundia, Patrick4 aut |
700 | 1 | a Quipourt, Valérie4 aut |
700 | 1 | a Marilier, Sophie4 aut |
700 | 1 | a Franon, Evelyne4 aut |
700 | 1 | a Bories, Lawrence4 aut |
700 | 1 | a Pader, Marie Laure4 aut |
700 | 1 | a Basset, Marie France4 aut |
700 | 1 | a Lapoujade, Bruno4 aut |
700 | 1 | a Faure, Valérie4 aut |
700 | 1 | a Li Yung Tong, Michael4 aut |
700 | 1 | a Malick-Loiseau, Christine4 aut |
700 | 1 | a Cazaban-Campistron, Evelyne4 aut |
700 | 1 | a Desclaux, Françoise4 aut |
700 | 1 | a Blatge, Colette4 aut |
700 | 1 | a Dantoine, Thierry4 aut |
700 | 1 | a Laubarie-Mouret, Cécile4 aut |
700 | 1 | a Saulnier, Isabelle4 aut |
700 | 1 | a Clément, Jean Pierre4 aut |
700 | 1 | a Picat, Marie Agnès4 aut |
700 | 1 | a Bernard-Bourzeix, Laurence4 aut |
700 | 1 | a Willebois, Stéphanie4 aut |
700 | 1 | a Désormais, Iléana4 aut |
700 | 1 | a Cardinaud, Noëlle4 aut |
700 | 1 | a Bonnefoy, Marc4 aut |
700 | 1 | a Livet, Pierre4 aut |
700 | 1 | a Rebaudet, Pascale4 aut |
700 | 1 | a Gédéon, Claire4 aut |
700 | 1 | a Burdet, Catherine4 aut |
700 | 1 | a Terracol, Flavien4 aut |
700 | 1 | a Pesce, Alain4 aut |
700 | 1 | a Roth, Stéphanie4 aut |
700 | 1 | a Chaillou, Sylvie4 aut |
700 | 1 | a Louchart, Sandrine4 aut |
700 | 1 | a Sudres, Kristel4 aut |
700 | 1 | a Lebrun, Nicolas4 aut |
700 | 1 | a Barro-Belaygues, Nadège4 aut |
700 | 1 | a Touchon, Jacques4 aut |
700 | 1 | a Bennys, Karim4 aut |
700 | 1 | a Gabelle, Audrey4 aut |
700 | 1 | a Romano, Aurélia4 aut |
700 | 1 | a Touati, Lynda4 aut |
700 | 1 | a Marelli, Cécilia4 aut |
700 | 1 | a Pays, Cécile4 aut |
700 | 1 | a Robert, Philippe4 aut |
700 | 1 | a Le Duff, Franck4 aut |
700 | 1 | a Gervais, Claire4 aut |
700 | 1 | a Gonfrier, Sébastien4 aut |
700 | 1 | a Gasnier, Yannick4 aut |
700 | 1 | a Bordes, Serge4 aut |
700 | 1 | a Begorre, Danièle4 aut |
700 | 1 | a Carpuat, Christian4 aut |
700 | 1 | a Khales, Khaled4 aut |
700 | 1 | a Lefebvre, Jean François4 aut |
700 | 1 | a Misbah El Idrissi, Samira4 aut |
700 | 1 | a Skolil, Pierre4 aut |
700 | 1 | a Salles, Jean Pierre4 aut |
700 | 1 | a Dufouil, Carole4 aut |
700 | 1 | a Lehéricy, Stéphane4 aut |
700 | 1 | a Chupin, Marie4 aut |
700 | 1 | a Mangin, Jean François4 aut |
700 | 1 | a Bouhayia, Ali4 aut |
700 | 1 | a Allard, Michèle4 aut |
700 | 1 | a Ricolfi, Frédéric4 aut |
700 | 1 | a Dubois, Dominique4 aut |
700 | 1 | a Bonceour Martel, Marie Paule4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t The Lancet Healthy Longevityg 5:2q 5:2x 2666-7568 |
856 | 4 8 | u https://gup.ub.gu.se/publication/336116 |
856 | 4 8 | u https://doi.org/10.1016/S2666-7568(23)00255-6 |
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