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Diagnostic and prognostic performance of the ratio between high-sensitivity cardiac troponin I and troponin T in patients with chest pain.

Eggers, Kai M., 1962- (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
Hammarsten, Ola (författare)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Department of Clinical Chemistry, Sahlgrenska University Hopsital, Göteborg, Sweden
Aldous, Sally J (författare)
Department of Cardiology, Christchurch Hospital, Christchurch, New Zealand
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Cullen, Louise (författare)
Emergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
Greenslade, Jaimi H (författare)
Emergency Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia
Lindahl, Bertil, 1957- (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
Parsonage, William A (författare)
Department of Cardiology, Royal Brisbane and Women’s Hospital, Brisbane, Australia
Pemberton, Christopher J (författare)
Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
Pickering, John W (författare)
Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Emergency Department, Christchurch Hospital, Christchurch, New Zealand
Richards, A Mark (författare)
Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand, Cardiovascular Research Institute, National University of Singapore, Singapore, Singapore
Troughton, Richard W (författare)
Christchurch Heart Institute, Department of Medicine, University of Ontago, Christchurch, New Zealand
Than, Martin P (författare)
Emergency Department, Christchurch Hospital, Christchurch, New Zealand
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 (creator_code:org_t)
2022-11-01
2022
Engelska.
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 17:11
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://gup.ub.gu.se...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Elevations of high-sensitivity cardiac troponin (hs-cTn) concentrations not related to type 1 myocardial infarction are common in chest pain patients presenting to emergency departments. The discrimination of these patients from those with type 1 myocardial infarction (MI) is challenging and resource-consuming. We aimed to investigate whether the hs-cTn I/T ratio might provide diagnostic and prognostic increment in this context.We calculated the hs-cTn I/T ratio in 888 chest pain patients having hs-cTnI (Abbott Laboratories) or hs-cTnT (Roche Diagnostics) concentrations above the respective 99th percentile at 2 hours from presentation. All patients were followed for one year regarding mortality.The median hs-cTn I/T ratio was 3.45 (25th, 75th percentiles 1.80-6.59) in type 1 MI patients (n = 408 ☯46.0%]), 1.18 (0.81-1.90) in type 2 MI patients (n = 56 ☯6.3%]) and 0.67 (0.39-1.12) in patients without MI. The hs-cTn I/T ratio provided good discrimination of type 1 MI from no type 1 MI (area under the receiver-operator characteristic curve 0.89 ☯95% confidence interval 0.86-0.91]), of type 1 MI from type 2 MI (area under the curve 0.81 ☯95% confidence interval 0.74-0.87]), and was associated with type 1 MI in adjusted analyses. The hs-cTn I/T ratio provided no consistent prognostic value.The hs-cTn I/T ratio appears to be useful for early diagnosis of type 1 MI and its discrimination from type 2 MI in chest pain patients presenting with elevated hs-cTn. Differences in hs-cTn I/T ratio values may reflect variations in hs-cTn release mechanisms in response to different types of myocardial injury.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Humans
Biomarkers
Chest Pain
complications
Myocardial Infarction
complications
Prognosis
Troponin I
Troponin T

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ref (ämneskategori)
art (ämneskategori)

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