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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03938naa a2200481 4500 | |
| 001 | oai:DiVA.org:umu-228740 | |
| 003 | SwePub | |
| 008 | 240822s2024 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/337478 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2287402 URI |
| 024 | 7 | a https://doi.org/10.1093/mr/roae0392 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/3374782 URI |
| 040 | a (SwePub)umud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hellman, Urban,d 1966-u Umeå universitet,Reumatologi,Immunologi/immunkemi4 aut0 (Swepub:umu)urhe0001 |
| 245 | 1 0 | a Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study |
| 264 | c 2024 | |
| 264 | 1 | b Oxford University Press,c 2024 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity.Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-alpha, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured.Results: Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-alpha, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity.Conclusion: Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a Ankylosing spondylitis | |
| 653 | a biomarkers | |
| 653 | a longitudinal observational study | |
| 653 | a Northern Sweden Health and Disease Study | |
| 653 | a radiographic axial spondyloarthritis | |
| 700 | 1 | a Lejon, Kristina,d 1967-u Umeå universitet,Immunologi/immunkemi4 aut0 (Swepub:umu)krle0001 |
| 700 | 1 | a Do, Lanu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)lado0003 |
| 700 | 1 | a Geijer, Mats4 aut |
| 700 | 1 | a Baraliakos, Xenofon4 aut |
| 700 | 1 | a Witte, Torsten4 aut |
| 700 | 1 | a Forsblad-d'Elia, Helenau Gothenburg University,Göteborgs universitet,Umeå universitet,Reumatologi,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xforhe |
| 710 | 2 | a Umeå universitetb Reumatologi4 org |
| 773 | 0 | t Modern Rheumatologyd : Oxford University Pressx 1439-7595x 1439-7609 |
| 856 | 4 | u https://doi.org/10.1093/mr/roae039y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1891433/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228740 |
| 856 | 4 8 | u https://doi.org/10.1093/mr/roae039 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/337478 |
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