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Sökning: onr:"swepub:oai:gup.ub.gu.se/337893" > Loading enhances gl...

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FältnamnIndikatorerMetadata
00003742naa a2200409 4500
001oai:gup.ub.gu.se/337893
003SwePub
008240717s2024 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3378932 URI
0247 a https://doi.org/10.1210/clinem/dgae3442 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bellman, Jakob4 aut
2451 0a Loading enhances glucose uptake in muscles, bones, and bone marrow of lower extremities in humans.
264 1c 2024
520 a Increased standing time has been associated with improved health, but the underlying mechanism is unclear.We herein investigate if increased weight loading increases energy demand and thereby glucose uptake (GU) locally in bone and/or muscle in the lower extremities.In this single-center clinical trial with randomized crossover design (ClinicalTrials.gov ID, NCT05443620), we enrolled 10 men with body mass index (BMI) between 30 and 35kg/m2. Participants were treated with both high load (standing with weight vest weighing 11% of body weight) and no load (sitting) on the lower extremities. GU was measured using whole-body quantitative positron emission tomography/computed tomography (PET/CT) imaging. The primary endpoint was the change in GU ratio between loaded bones (i.e. femur and tibia) and non-loaded bones (i.e. humerus).High load increased the GU ratio between lower and upper extremities in cortical diaphyseal bone (e.g. femur/humerus ratio increased by 19%, p=0.029), muscles (e.g. m. quadriceps femoris/m. triceps brachii ratio increased by 28%, p=0.014) and in certain bone marrow regions (femur/humerus diaphyseal bone marrow region ratio increased by 17%, p=0.041). Unexpectedly, we observed the highest GU in the bone marrow region of vertebral bodies, but its GU was not affected by high load.Increased weight-bearing loading enhances GU in muscles, cortical bone, and bone marrow of the exposed lower extremities. This could be interpreted as increased local energy demand in bone and muscle caused by increased loading. The physiological importance of the increased local GU by static loading remains to be determined.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Sjöros, Tanja4 aut
7001 a Hägg, Daniel,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhagda
7001 a Atencio Herre, Erika4 aut
7001 a Hieta, Janina4 aut
7001 a Eskola, Olli4 aut
7001 a Laitinen, Kirsi4 aut
7001 a Nuutila, Pirjo4 aut
7001 a Jansson, John-Olov4 aut
7001 a Jansson, Per-Anders4 aut
7001 a Kalliokoski, Kari4 aut
7001 a Roivainen, Anne4 aut
7001 a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl
7102 a Göteborgs universitetb Centre for Bone and Arthritis Research4 org
7730 t The Journal of clinical endocrinology and metabolismx 1945-7197
8564 8u https://gup.ub.gu.se/publication/337893
8564 8u https://doi.org/10.1210/clinem/dgae344

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