Acromegaly management in the Nordic countries: A Delphi consensus survey

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Acromegaly management in the Nordic countries: A Delphi consensus survey

Arlien-Soborg, Mai C. (författare): Aarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

Dal, Jakob (författare): Aalborg Univ Hosp, Denmark; Steno Diabet Ctr North Jutland, Denmark,Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark; Steno Diabetes Center North Jutland, Aalborg, Denmark

Heck, Ansgar (författare): Oslo Univ Hosp, Norway,Oslo University Hospital, Oslo, Norway

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Stochholm, Kirstine (författare): Aarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

Husted, Eigil (författare): Aalborg Univ Hosp, Denmark,Department of Endocrinology, Aalborg University Hospital, Aarhus, Denmark

Feltoft, Claus Larsen (författare): Copenhagen Univ Hosp Herlev & Gentofte, Denmark,Copenhagen University Hospital—Herlev and Gentofte, Kobenhavn, Denmark

Rasmussen, ase Krogh (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Feldt-Rasmussen, Ulla (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Andreassen, Mikkel (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Klose, Marianne Christina (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Nielsen, Torben Leo (författare): Odense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark

Andersen, Marianne Skovsager (författare): Odense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark

Christensen, Louise Lehmann (författare): Odense Univ Hosp, Denmark,Odense University Hospital, Odense, Denmark

Krogh, Jesper (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Jarlov, Anne (författare): Copenhagen Univ Hosp, Denmark,Copenhagen University Hospital, Kobenhavn, Denmark

Bollerslev, Jens (författare): Oslo Univ Hosp, Norway,Oslo University Hospital, Oslo, Norway

Nermoen, Ingrid (författare): Akershus Univ Hosp, Norway,Akershus University Hospital, lørenskog, Norway

Oksnes, Marianne (författare): Haukeland Hosp, Norway,Haukeland University Hospital, Bergen, Norway

Dahlqvist, Per (författare): Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden

Olsson, Tommy (författare): Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands University Hospital, Umeå, Sweden

Berinder, Katarina (författare): Karolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden

Hoybye, Charlotte (författare): Karolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden

Petersson, Maria (författare): Karolinska Univ Hosp, Sweden,Karolinska University Hospital, Sweden

Akerman, Anna-karin (författare): Orebro Univ, Sweden,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden

Wahlberg, Jeanette (författare): Orebro Univ Hosp, Sweden,Department of Medicine, Örebro University Hospital, Örebro, Sweden

Ekman, Bertil (författare): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN,Region Östergötland, Endokrinmedicinska kliniken,Department of Endocrinology and the Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden

Engstrom, Britt Eden (författare): Uppsala Univ Hosp, Sweden,Uppsala University Hospital, Uppsala, Sweden

Johannsson, Gudmundur, 1960 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden

Ragnarsson, Oskar (författare): Sahlgrens Univ Hosp, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden

Olsson, Daniel S, 1983 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden,Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg & Sahlgrenska University Hospital, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Sigurjonsdottir, Helga agusta (författare): Natl Univ Hosp Iceland, Iceland; Univ Iceland, Iceland,The National University Hospital of Iceland, Gothenburg, Iceland; School of Medicine, University of Iceland, Reykjavik, Iceland

Fougner, Stine Lyngvi (författare): Trondheim Reg & Univ Hosp, Norway; Norwegian Univ Sci & Technol NTNU, Norway,Department of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Matikainen, Niina (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Vehkavaara, Satu (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Metso, Saara (författare): Tampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland

Jaatinen, Pia (författare): Tampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland

Haemalainen, Paeivi (författare): Tampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland

Rintamaki, Reeta (författare): Kuopio Univ Hosp, Finland,Kuopio University Hospital, Kuopio, Finland

Yliaska, Iina (författare): Oulu Univ Hosp, Finland,Oulu University Hospital, Oulu, Finland

Immonen, Heidi (författare): Turku Univ Hosp, Finland,Turku University Hospital, Turku, Finland

Makimattila, Sari (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Cederberg-Tamminen, Henna (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Viukari, Marianna (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Nevalainen, Pasi (författare): Tampere Univ Hosp, Finland,Tampere University Hospital, Tampere, Finland

Nuutila, Pirjo (författare): Turku Univ Hosp, Finland,Turku University Hospital, Turku, Finland

Schalin-Jantti, Camilla (författare): Helsinki Univ Hosp, Finland,Helsinki University Hospital, Helsinki, Finland

Burman, Pia (författare): Lund Univ, Sweden,Skåne University Hospital, Lund University, Malmö, Sweden

Jorgensen, Jens Otto Lunde (författare): Aarhus Univ Hosp, Denmark,Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark

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(creator_code:org_t)

WILEY, 2024
2024
Engelska.
Ingår i: CLINICAL ENDOCRINOLOGY. - : WILEY. - 0300-0664 .- 1365-2265.

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

ObjectiveAcromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly in the Nordic countries.MethodsA Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow-up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert-type scale (1-7). Consensus was defined as >= 80% of panelists rating their agreement as >= 5 or <= 3 on the Likert-type scale.ResultsConsensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first-generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first-generation SSA and pegvisomant as second- or third-line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists.ConclusionThis consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence-based data.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

acromegaly
Delphi
dopamine agonist
growth hormone
growth hormone receptor antagonist
insulin-like growth factor i
somatostatin
acromegaly; Delphi; dopamine agonist; growth hormone; growth hormone receptor antagonist; insulin-like growth factor i; somatostatin

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Av författaren/redakt...: Arlien-Soborg, M ...; Dal, Jakob; Heck, Ansgar; Stochholm, Kirst ...; Husted, Eigil; Feltoft, Claus L ...; visa fler...; Rasmussen, ase K ...; Feldt-Rasmussen, ...; Andreassen, Mikk ...; Klose, Marianne ...; Nielsen, Torben ...; Andersen, Marian ...; Christensen, Lou ...; Krogh, Jesper; Jarlov, Anne; Bollerslev, Jens; Nermoen, Ingrid; Oksnes, Marianne; Dahlqvist, Per; Olsson, Tommy; Berinder, Katari ...; Hoybye, Charlott ...; Petersson, Maria; Akerman, Anna-ka ...; Wahlberg, Jeanet ...; Ekman, Bertil; Engstrom, Britt ...; Johannsson, Gudm ...; Ragnarsson, Oska ...; Olsson, Daniel S ...; Sigurjonsdottir, ...; Fougner, Stine L ...; Matikainen, Niin ...; Vehkavaara, Satu; Metso, Saara; Jaatinen, Pia; Haemalainen, Pae ...; Rintamaki, Reeta; Yliaska, Iina; Immonen, Heidi; Makimattila, Sar ...; Cederberg-Tammin ...; Viukari, Mariann ...; Nevalainen, Pasi; Nuutila, Pirjo; Schalin-Jantti, ...; Burman, Pia; Jorgensen, Jens ...; visa färre...

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