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A proinflammatory p...
A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions
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- Bellner, Lars, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Bergh Thorén, Fredrik, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology,University of Gothenburg, Sweden
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- Nygren, Erik, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology,University of Gothenburg, Sweden
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- Liljeqvist, Jan-Åke, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology,University of Gothenburg, Sweden
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- Karlsson, Anna, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Eriksson, Kristina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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(creator_code:org_t)
- American Association of Immunologists, 2005
- 2005
- Engelska.
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Ingår i: J Immunol. - : American Association of Immunologists. ; 174:4, s. 2235-2241
- Relaterad länk:
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https://www.jimmunol...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- We have identified a synthetic peptide derived from the secreted portion of HSV type 2 glycoprotein G, denoted gG-2p20, which has proinflammatory properties in vitro. The gG-2p20 peptide, corresponding to aa 190-205 of glycoprotein G-2, was a chemoattractant for both monocytes and neutrophils in a dose-dependent fashion, and also induced the release of reactive oxygen from these cells. The receptor mediating the responses was identified as the formyl peptide receptor. The gG-2p20-induced activation of phagocytes had a profound impact on NK cell functions. The reactive oxygen species produced by gG-2p20-activated phagocytes both inhibited NK cell cytotoxicity and accelerated the apoptotic cell death in NK cell-enriched lymphocyte populations. Hence, we have for the first time been able to identify a potential function of the secreted portion of HSV-2 glycoprotein G. We propose that the proinflammatory gG-2p20 peptide identified could contribute to a reduced function and viability of NK cells during HSV-2 infection due to its ability to recruit and activate phagocytic cells.
Nyckelord
- Amino Acid Sequence
- Apoptosis/immunology
- Chemotaxis
- Leukocyte/immunology
- Cytotoxicity
- Immunologic/immunology
- Enzyme Induction/immunology
- Herpesvirus 2
- Human/*immunology
- Humans
- Immunosuppressive Agents/chemical synthesis/immunology
- Inflammation Mediators/chemical synthesis/*physiology
- Killer Cells
- Natural/*immunology/pathology/virology
- Macrophage Activation/immunology
- Molecular Sequence Data
- Monocytes/*immunology/pathology/virology
- NADPH Oxidase/biosynthesis/metabolism
- Neutrophil Activation/immunology
- Neutrophils/enzymology/*immunology/pathology/virology
- Peptide Fragments/chemical synthesis/*physiology
- Pertussis Toxin/pharmacology
- Phagocytes/enzymology/immunology/pathology/virology
- Reactive Oxygen Species/metabolism
- Receptors
- Formyl Peptide/physiology
- Research Support
- Non-U.S. Gov't
- Viral Envelope Proteins/chemical synthesis/*physiology
- glycoprotein g 2p20
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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