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Spirobicyclo[2.2.2]...
Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol)
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Almqvist, Fredrik (författare)
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Manner, S. (författare)
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Thornqvist, V. (författare)
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Berg, U. (författare)
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- Wallin, Margareta, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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Frejd, T. (författare)
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(creator_code:org_t)
- Royal Society of Chemistry (RSC), 2004
- 2004
- Engelska.
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Ingår i: Organic & Biomolecular Chemistry. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 2:21, s. 3085-3090
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The formylated spirobyclic alcohol 8a was computer modeled to be a mimetic of paclitaxel. In this model, the formyl group was used as a truncated paclitaxel side chain in order to reduce the computational work. Compound 8c, carrying the paclitaxel side chain, was synthesized in six steps from optically active 1,3-diketone 12. Microtubule stabilization was not observed for 8c, indicating that the model needs to be adjusted.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- enantioselective total-synthesis
- 1st total-synthesis
- beta-tubulin
- stereocontrolled synthesis
- michael reaction
- c-alkylation
- pinene path
- side-chain
- ketones
- ring
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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