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Effects of pretreat...
Effects of pretreatment with a xanthine oxidase inhibitor on free radical levels during carotid endarterectomy.
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Waters, S (författare)
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- Fae, Anita, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology
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- Gondalia, Jagdish Shivlal, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology
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Holm, J (författare)
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Karlström, L (författare)
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Nilsson, U (författare)
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- Jonsson, Olof, 1941 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för urologi,Institute of Surgical Sciences, Department of Urology
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(creator_code:org_t)
- 2009-07-07
- 2004
- Engelska.
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Ingår i: Free Radic Res. - : Informa UK Limited. - 1071-5762 .- 1029-2470. ; 38:3, s. 283-293
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Free radicals contribute to the tissue damage caused by ischaemia-reperfusion. The aim of the present study was to investigate whether preoperative antioxidant therapy (allopurinol) affects free radical levels in cerebral venous blood in connection with surgery for carotid artery stenosis. Materials and methods: Twenty-five patients were randomised into the study. Thirteen were controls and 12 were pretreated with allopurinol the day before surgery. Before, during and after surgery, blood samples were drawn from the ipsilateral jugular vein. Radical levels were measured using the spin trap technique ex vivo using OXANOH as the spin trap. Multivariate statistics were used with Principal Component Analysis and Partial Least Square regression analysis. Results: Radical levels increased with diabetes, high leukocyte count, high creatinine and a high degree of contralateral stenosis. Radical levels decreased with high age, blood pressure, collateral circulation as well as operation for left-side carotid artery stenosis. After pretreatment with allopurinol, several of the relationships noted in the control group were eliminated, i.e. leukocyte count, side of operation, Betapred pretreatment and collateral circulation. Conclusions: Radical levels can be determined in connection with surgery for carotid artery stenosis using an ex vivo spin trap method. With preoperative antioxidant therapy the relationships between enhanced radical levels and clinical data, as seen in control subjects, disappeared. This might indicate a beneficial effect of preoperative pretreatment with antioxidants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Carotid artery; Stenosis; Antioxidants; Spin trap; Radical production
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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