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A putative role for...
A putative role for psoriasin in breast tumor progression
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Krop, I. (författare)
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Marz, A. (författare)
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- Carlsson, Hanna, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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visa fler...
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Li, X. (författare)
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Bloushtain-Qimron, N. (författare)
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Hu, M. (författare)
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Gelman, R. (författare)
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Sabel, M. S. (författare)
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Schnitt, S. (författare)
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Ramaswamy, S. (författare)
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Kleer, C. G. (författare)
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- Enerbäck, Charlotta, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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Polyak, K. (författare)
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Cancer Research. ; 65:24, s. 11326-34
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Psoriasin (S100A7) was identifi;ed as a gene highly expressed in psoriatic keratinocytes and highly and more frequently expressed in ductal carcinoma in situ (DCIS) than in invasive breast carcinomas (IBC), suggesting a potential role in tumor progression. Psoriasin expression is associated with poor prognostic factors in both DCIS and IBC. Several putative functions have been proposed for psoriasin in various disease types, but none of these can fully explain its involvement in breast tumor progression. Here, we show that down-regulation of endogenous psoriasin expression via stable short hairpin RNAs in a human IBC cell line (MDA-MB-468) increases cell migration and invasion without influencing cell proliferation and survival in vitro but inhibits tumor growth in vivo. These seemingly paradoxical results are potentially explained by the dramatic up-regulation and down-regulation of matrix metalloproteinase-13 and vascular endothelial growth factor (VEGF), respectively, observed in cells with decreased psoriasin levels compared with controls. Correlating with this, high psoriasin expression in human IBC is associated with increased angiogenesis and worse clinical outcome, and psoriasin mRNA levels are coordinately regulated with VEGF and other genes related to hypoxia and mitochondrial reactive oxygen species (ROS). Based on these results, we propose that psoriasin may play a role in breast tumor progression by promoting angiogenesis and enhancing the selection for cells that overcome its anti-invasive function. This hypothesis may explain why psoriasin expression is highest in high-grade and/or estrogen receptor-negative tumors, as these are associated with increased hypoxia and ROS, a setting in which the angiogenic effects of psoriasin are most important.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Animals
- Apoptosis
- Breast Neoplasms/blood supply/*metabolism/pathology
- Calcium-Binding Proteins/*physiology
- Carcinoma
- Intraductal
- Noninfiltrating/blood supply/metabolism/pathology
- Collagenases/metabolism
- Disease Progression
- Down-Regulation
- Female
- Humans
- Matrix Metalloproteinase 13
- Mice
- Mice
- Nude
- Neovascularization
- Pathologic/*metabolism
- RNA
- Messenger/genetics/metabolism
- RNA
- Small Interfering/genetics
- Receptors
- Estrogen/metabolism
- Tumor Cells
- Cultured
- Tumor Markers
- Biological/physiology
- Vascular Endothelial Growth Factor A/*metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Krop, I.
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Marz, A.
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Carlsson, Hanna, ...
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Li, X.
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Bloushtain-Qimro ...
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Hu, M.
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visa fler...
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Gelman, R.
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Sabel, M. S.
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Schnitt, S.
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Ramaswamy, S.
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Kleer, C. G.
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Enerbäck, Charlo ...
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Polyak, K.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Dermatologi och ...
- Artiklar i publikationen
- Cancer Research
- Av lärosätet
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Göteborgs universitet