LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients

• Human cytomegalovirus infection is a major cause of morbidity after lung transplantation. LIR-1 (leucocyte immunoglobulin-like receptor-1) is an inhibitory cell surface receptor that has high affinity for an MHC class I homologue (UL18) encoded by human cytomegalovirus. We aimed to investigate whether reactivation of human cytomegalovirus affects the expression of LIR-1. We measured LIR-1 expression on peripheral blood lymphocytes from 13 lung-transplant recipients and established human cytomegalovirus load using PCR. Eight patients developed cytomegalovirus disease. The percentage of cells expressing LIR-1 increased in the patients who developed cytomegalovirus disease several weeks before viral DNA was detectable by PCR. Measurement of LIR-1 expression might allow early identification of cytomegalovirus disease in lung-transplant patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

Adult

Aged

Antigens

CD/*blood

Cytomegalovirus Infections/diagnosis/*immunology

Female

Follow-Up Studies

Humans

Immune Tolerance/immunology

Lung Transplantation/*immunology

Lymphocytes/*immunology

Male

Middle Aged

Opportunistic Infections/diagnosis/*immunology

Receptors

Immunologic/*blood

Risk Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)