Sökning: onr:"swepub:oai:gup.ub.gu.se/45698" >
TOP2A and HER2 gene...
TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer
-
- Villman, Kenneth (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
-
Sjostrom, J. (författare)
-
Heikkila, R. (författare)
-
visa fler...
-
- Hultborn, Ragnar, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
-
- Malmström, Per (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Bengtsson, Nils-Olof (författare)
- Umeå universitet,Onkologi
-
Soderberg, M. (författare)
-
Saksela, E. (författare)
-
- Blomqvist, C. (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
-
visa färre...
-
(creator_code:org_t)
- 2009-07-08
- 2006
- Engelska.
-
Ingår i: Acta Oncol. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 45:5, s. 590-6
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A) and HER2 genes as predictors of response to chemotherapy in advanced breast cancer. Gene copy number of TOP2A and HER2 were analysed with chromogenic in situ hybridization (CISH) on paraffin-embedded tissue sections from the primary tumour of 85 patients treated with anthracycline containing chemotherapy. TOP2A gene amplification was present in 14 (16%) and HER2 gene amplification in 38 (45%) of the primary tumours. Two of the 14 cases with TOP2A amplification were amplified without concurrent HER2 amplification. Neither TOP2A nor HER2 gene amplification were significantly associated with response to chemotherapy (p = 0.35 and p = 0.49, respectively).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Anthracyclines/*therapeutic use
- Antibiotics
- Antineoplastic/therapeutic use
- Antigens
- Neoplasm/analysis/drug effects/*genetics
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use
- Breast Neoplasms/diagnosis/*drug therapy/*genetics
- Chromogenic Compounds/diagnostic use
- DNA Topoisomerases
- Type II
- Eukaryotic/analysis/drug effects/*genetics
- DNA-Binding Proteins/analysis/drug effects/*genetics
- Disease Progression
- Female
- *Gene Amplification
- Genes
- erbB-2/drug effects/*genetics
- Humans
- In Situ Hybridization
- Middle Aged
- Predictive Value of Tests
- Sensitivity and Specificity
- Tissue Array Analysis/methods
- Treatment Outcome
- Tumor Markers
- Biological/analysis/*genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas