Sökning: onr:"swepub:oai:gup.ub.gu.se/47437" >
Liver transplantati...
Abstract
Ämnesord
Stäng
- BACKGROUND/AIMS: Hepatobiliary malignancies are frequently seen in primary sclerosing cholangitis (PSC) and they complicate the evaluation of patients and timing of liver transplantation. METHODS: Data from all Nordic PSC patients listed for liver transplantation during 1990-2001 were recorded prospectively. Predictors of hepatobiliary malignancy and patient survival rates have been analysed. RESULTS: Hepatobiliary malignancy was found in 52/255 (20%) patients accepted to the waiting list. Recent diagnosis of PSC, no ursodeoxycholic acid (UDCA) treatment, clinical suspicion and previous colorectal-cancer were predictors of malignancy. Among 89 patients with a strong suspicion of malignancy prior to acceptance, 35 (39%) had confirmed malignancy. A clinical suspicion had been raised in 35/52 (67%) patients with malignancy. Malignancy was found in 31/223 patients who received a liver allograft. The 1-, 3- and 5-year patient survival rates following transplantation for patients with PSC and cholangiocarcinoma were 65, 35 and 35%, respectively. CONCLUSIONS: Hepatobiliary malignancy is suspected in 1/3 of the PSC patients and found in 1/5. Although cholangiocarcinoma is regarded as a contraindication to liver transplantation (LTX), PSC patients with cholangiocarcinoma had a 35% 5-year survival following transplantation.
Nyckelord
- Adult
- Biliary Tract Neoplasms/*complications
- Carcinoma
- Hepatocellular/complications
- Cholangiocarcinoma/complications
- Cholangitis
- Sclerosing/*complications/mortality/*surgery
- Colorectal Neoplasms/complications
- Female
- Gallbladder Neoplasms/complications
- Humans
- Liver Neoplasms/*complications
- *Liver Transplantation/contraindications
- Male
- Middle Aged
- Prognosis
- Survival Rate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Brandsaeter, B.
-
Isoniemi, H.
-
Broome, U.
-
Olausson, Michae ...
-
Backman, L.
-
Hansen, B.
-
visa fler...
-
Schrumpf, E.
-
Oksanen, A.
-
Ericzon, B. G.
-
Hockerstedt, K.
-
Makisalo, H.
-
Kirkegaard, P.
-
Friman, Styrbjör ...
-
Bjoro, K.
-
visa färre...
- Artiklar i publikationen
-
Journal of hepat ...
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet