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Effect of gastric b...
Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles
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Mancini, M. C. (författare)
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Costa, A. P. (författare)
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de Melo, M. E. (författare)
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visa fler...
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Cercato, C. (författare)
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Giannella-Neto, D. (författare)
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Garrido, A. B., Jr. (författare)
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- Rosberg, Sten, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Albertsson-Wikland, Kerstin, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Villares, S. M. (författare)
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Halpern, A. (författare)
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visa färre...
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Obesity (Silver Spring). ; 14:3, s. 383-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- OBJECTIVE: The purpose of this study was to analyze growth hormone (GH) concentrations in obese women before and after Roux-en-Y gastric bypass (RYGBP) and how resulting changes in weight, fat mass, ghrelin levels, and insulin sensitivity affect GH secretion. RESEARCH METHODS AND PROCEDURES: Blood was sampled at 20-minute intervals for 24 hours in 10 non-diabetic premenopausal severely obese women before and 6 months after RYGBP. GH concentrations were measured in all samples, and serum ghrelin was collected at five time-points. RESULTS: After a 27% BMI drop (55.9 +/- 6.2 to 40.7 +/- 5.8 kg/m(2)), blunted GH profiles underwent partial recovery. Basal, postprandial, and mean ghrelin concentrations were not changed. A negative correlation was found between mean GH levels and insulin and homeostasis model assessment (p < 0.01). BMI accounted for 54% of GH variation. DISCUSSION: Partial recovery of GH secretion after RYGBP-induced weight loss suggests that a blunted secretion is not a causal factor of obesity but a consequence of the obese state and does not seem to be ghrelin-level dependent.
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Mancini, M. C.
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Costa, A. P.
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de Melo, M. E.
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Cercato, C.
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Giannella-Neto, ...
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Garrido, A. B., ...
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visa fler...
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Rosberg, Sten, 1 ...
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Albertsson-Wikla ...
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Villares, S. M.
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Halpern, A.
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visa färre...
- Artiklar i publikationen
- Obesity (Silver ...
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Göteborgs universitet