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Monocyte chemoattra...
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Murdolo, Giuseppe,1966Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
(författare)
Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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The Endocrine Society,2007
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/50448
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https://gup.ub.gu.se/publication/50448URI
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https://doi.org/10.1210/jc.2006-2814DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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CONTEXT: The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in obesity-associated chronic inflammation, insulin resistance, and atherosclerosis. OBJECTIVES: The objectives of this study were to: 1) characterize the interstitial levels and the gene expression of MCP-1 in the sc abdominal adipose tissue (SCAAT), 2) elucidate the response of MCP-1 to acute hyperinsulinemia, and 3) determine the relationship between MCP-1 and arterial stiffness. DESIGN: Nine lean (L) and nine uncomplicated obese (OB) males were studied in the fasting state and during a euglycemic-hyperinsulinemic clamp combined with the microdialysis technique. Interstitial and serum MCP-1 (iMCP-1 and sMCP-1, respectively) levels, pulse wave analysis, and SCAAT biopsies were characterized at baseline and after hyperinsulinemia. RESULTS: OB showed elevated sMCP-1 (P < 0.01) but similar iMCP-1 levels as compared with L. Basal iMCP-1 concentrations were considerably higher than sMCP-1 (P < 0.0001), and a gradient between iMCP-1 and sMCP-1 levels was maintained throughout the hyperinsulinemia. At baseline, SCAAT gene expression profile revealed a "co-upregulation" of MCP-1, MCP-2, macrophage inflammatory protein-1alpha, and CD68 in OB, and whole-body glucose disposal inversely correlated with the MCP-1 gene expression. After hyperinsulinemia, MCP-1 and MCP-2 mRNA levels significantly increased in L, but not in OB. Finally, sMCP-1 excess in the OB positively correlated with the stiffer vasculature. CONCLUSIONS: These observations demonstrate similar interstitial concentrations and a differential gene response to hyperinsulinemia of MCP-1 in the SCAAT from L and OB individuals. In human obesity, we suggest the SCAAT MCP-1 gene overexpression as a biomarker of an "inflamed" adipose organ and impaired glucose metabolism.
Ämnesord och genrebeteckningar
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Adipocytes/cytology/physiology
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Adult
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Biological Markers
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Cell Size
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Chemokine CCL2/*genetics
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Diabetes Mellitus
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Type 2/*genetics/immunology/physiopathology
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Gene Expression Profiling
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Gene Expression Regulation/immunology
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*Genetic Markers
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Humans
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Hyperinsulinism/genetics/immunology/physiopathology
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Insulin/*blood
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Insulin Resistance
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Male
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Middle Aged
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Obesity/genetics/immunology/physiopathology
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Subcutaneous Fat/*physiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hammarstedt, Ann,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xhaman
(författare)
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Sandqvist, Madelene,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsamad
(författare)
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Schmelz, M.
(författare)
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Herder, C.
(författare)
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Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmiul
(författare)
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Jansson, Per-Anders,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xjansp
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:J Clin Endocrinol Metab: The Endocrine Society92:7, s. 2688-950021-972X
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Ingår i:The Journal of Clinical Endocrinology & Metabolism: The Endocrine Society92:7, s. 2688-951945-7197
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