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Immature porcine kn...
Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.
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- Vasara, Anna I (författare)
- Department of Orthopaedics, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland
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- Hyttinen, M M (författare)
- Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Lammi, Mikko, 1961- (författare)
- Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Pulliainen, O (författare)
- Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Jurvelin, Jukka S (författare)
- jukka.jurvelin@uef.fi Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Applied Physics, University of Kuopio, Kuopio, Finland
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- Peterson, Lars, 1936 (författare)
- Department of Orthopedics, Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Lindahl, Anders, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Helminen, H J (författare)
- Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland
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- Kiviranta, Ilkka (författare)
- Department of Surgery, Division of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. - : Elsevier BV. - 1063-4584 .- 1522-9653. ; 14:10, s. 1066-74
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: The purpose of this study was to find out how deep chondral lesions heal in growing animals spontaneously and after autologous chondrocyte transplantation. METHODS: A 6mm deep chondral lesion was created in the knee joints of 57 immature pigs and repaired with autologous chondrocyte transplantation covered with periosteum or muscle fascia, with periosteum only, or left untreated. After 3 and 12 months, the repair tissue was evaluated with International Cartilage Repair Society (ICRS) macroscopic grading, modified O'Driscoll histological scoring, and staining for collagen type II and hyaluronan, and with toluidine blue and safranin-O staining for glycosaminoglycans. The repair tissue structure was also examined with quantitative polarized light microscopy and indentation analysis of the cartilage stiffness. RESULTS: The ICRS grading indicated nearly normal repair tissue in 65% (10/17) after the autologous chondrocyte transplantation and 86% (7/8) after no repair at 3 months. At 1 year, the repair tissue was nearly normal in all cases in the spontaneous repair group and in 38% (3/8) in the chondrocyte transplantation group. In most cases, the cartilage repair tissue stained intensely for glycosaminoglycans and collagen type II indicating repair tissue with true constituents of articular cartilage. There was a statistical difference in the total histological scores at 3 months (P=0.028) with the best repair in the spontaneous repair group. A marked subchondral bone reaction, staining with toluidine blue and collagen type II, was seen in 65% of all animals. CONCLUSIONS: The spontaneous repair ability of full thickness cartilage defects of immature pigs is significant and periosteum or autologous chondrocytes do not bring any additional benefits to the repair.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Animals
- Cartilage
- Articular
- injuries
- surgery
- Chondrocytes
- transplantation
- Collagen Type II
- chemistry
- Glycosaminoglycans
- chemistry
- Hindlimb
- Hyaluronic Acid
- chemistry
- Knee Joint
- surgery
- Periosteum
- transplantation
- Swine
- Transplantation
- Autologous
- Wound Healing
- Articular cartilage
- cell research
- ortopedi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Vasara, Anna I
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Hyttinen, M M
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Lammi, Mikko, 19 ...
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Pulliainen, O
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Jurvelin, Jukka ...
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Peterson, Lars, ...
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visa fler...
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Lindahl, Anders, ...
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Helminen, H J
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Kiviranta, Ilkka
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Osteoarthritis a ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet