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Poly-L-D-lactic aci...
Poly-L-D-lactic acid scaffold in the repair of porcine knee cartilage lesions.
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- Pulliainen, Outi (författare)
- Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
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- Vasara, Anna I (författare)
- Department of Orthopaedics, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland
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- Hyttinen, M M (författare)
- Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland
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- Tiitu, Virpi (författare)
- Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland; Department of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
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- Valonen, Piia (författare)
- Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland; Department of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
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- Jurvelin, Jukka S (författare)
- Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Physics, University of Kuopio, Kuopio, Finland
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- Kellomäki, M (författare)
- Institute of Biomaterials, Tampere University of Technology, Tampere, Finland
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- Peterson, Lars, 1936 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics,Department of Orthopaedics, Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Lindahl, Anders, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Göteborg University, Göteborg, Sweden; Sahlgrenska University Hospital, Göteborg, Sweden
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- Kiviranta, Ilkka (författare)
- Department of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland
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- Lammi, Mikko, 1961- (författare)
- Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2007
- 2007
- Engelska.
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Ingår i: Tissue engineering. - : Mary Ann Liebert Inc. - 1076-3279 .- 1557-8690. ; 13:6, s. 1347-55
- Relaterad länk:
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http://online.lieber...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Articular cartilage injuries cause a major clinical problem because of the negligible repair capacity of cartilage. Autologous chondrocyte transplantation is a surgical method developed to repair cartilage lesions. In the operation, cartilage defect is covered with a periosteal patch and the suspension of cultured autologous chondrocytes is injected into the lesion site. The method can form good repair tissue, but new techniques are needed to make the operation easier and to increase the postoperative biomechanical properties of the repair tissue. In this study, we investigated poly-L,D-lactic acid (PLDLA) scaffolds alone or seeded with autologous chondrocytes in the repair of circular 6-mm cartilage lesions in immature porcine knee joints. Spontaneous repair was used as a reference. Histologic evaluation of the repair tissue showed that spontaneous repair exhibited higher scores than either PLDLA scaffold group (with or without seeded chondrocytes). The scaffold material was most often seen embedded in the subchondral bone underneath the defect area, probably because of the hardness of the PLDLA material. However, some of the cell-seeded and nonseeded scaffolds contained cartilaginous tissue, suggesting that invasion of mesenchymal cells inside nonseeded scaffolds had occurred. Hyaluronan deposited in the scaffold had possibly acted as a chemoattractant for the cell recruitment. In conclusion, the PLDLA scaffold material used in this study was obviously mechanically too hard to be used for cartilage repair in immature animals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Animals
- Cells
- Cultured
- Chondrocytes
- pathology
- transplantation
- Fractures
- Cartilage
- pathology
- surgery
- Guided Tissue Regeneration
- methods
- Knee Injuries
- pathology
- surgery
- Lactic Acid
- chemistry
- therapeutic use
- Polymers
- chemistry
- therapeutic use
- Swine
- Tissue Engineering
- methods
- Treatment Outcome
- Articular cartilage
- cell research
- ortopedi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Pulliainen, Outi
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Vasara, Anna I
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Hyttinen, M M
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Tiitu, Virpi
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Valonen, Piia
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Jurvelin, Jukka ...
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visa fler...
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Kellomäki, M
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Peterson, Lars, ...
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Lindahl, Anders, ...
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Kiviranta, Ilkka
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Lammi, Mikko, 19 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Tissue engineeri ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet