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Insulin sensitivity...
Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women.
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Cornier, Marc-Andre (författare)
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Donahoo, W Troy (författare)
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Pereira, Rocio (författare)
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visa fler...
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Gurevich, Inga (författare)
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- Westergren, Rickard, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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- Enerbäck, Sven, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry
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Eckel, Peter J (författare)
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Goalstone, Marc L (författare)
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Hill, James O (författare)
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Eckel, Robert H (författare)
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Draznin, Boris (författare)
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Obesity research. - 1071-7323. ; 13:4, s. 703-9
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- OBJECTIVE: To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets. RESEARCH METHODS AND PROCEDURES: Obese nondiabetic insulin-sensitive (fasting insulin < 10 microU/mL; n = 12) and obese nondiabetic insulin-resistant (fasting insulin > 15 microU/mL; n = 9) women (23 to 53 years old) were randomized to either a high carbohydrate (CHO) (HC)/low fat (LF) (60% CHO, 20% fat) or low CHO (LC)/high fat (HF) (40% CHO, 40% fat) hypocaloric diet. Primary outcome measures after a 16-week dietary intervention were: changes in body weight (BW), Si, resting metabolic rate, and fasting lipids. RESULTS: Insulin-sensitive women on the HC/LF diet lost 13.5 +/- 1.2% (p < 0.001) of their initial BW, whereas those on the LC/HF diet lost 6.8 +/- 1.2% (p < 0.001; p < 0.002 between the groups). In contrast, among the insulin-resistant women, those on the LC/HF diet lost 13.4 +/- 1.3% (p < 0.001) of their initial BW as compared with 8.5 +/- 1.4% (p < 0.001) lost by those on the HC/LF diet (p < 0.04 between two groups). These differences could not be explained by changes in resting metabolic rate, activity, or intake. Overall, changes in Si were associated with the degree of weight loss (r = -0.57, p < 0.05). DISCUSSION: The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women. For maximal benefit, the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si.
Nyckelord
- Adult
- Basal Metabolism
- Body Mass Index
- Diet
- Reducing
- Dietary Carbohydrates
- administration & dosage
- Dietary Fats
- administration & dosage
- Energy Intake
- Energy Metabolism
- Fasting
- Female
- Humans
- Insulin
- blood
- Insulin Resistance
- Middle Aged
- Obesity
- physiopathology
- therapy
- Treatment Outcome
- Weight Loss
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Cornier, Marc-An ...
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Donahoo, W Troy
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Pereira, Rocio
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Gurevich, Inga
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Westergren, Rick ...
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Enerbäck, Sven, ...
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visa fler...
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Eckel, Peter J
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Goalstone, Marc ...
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Hill, James O
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Eckel, Robert H
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Draznin, Boris
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visa färre...
- Artiklar i publikationen
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Obesity research
- Av lärosätet
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Göteborgs universitet