Sökning: onr:"swepub:oai:gup.ub.gu.se/53031" >
Acute leukaemia in ...
Acute leukaemia in children with Down syndrome: a population-based Nordic study
-
Zeller, B. (författare)
-
- Gustafsson, G. (författare)
- Karolinska Institutet
-
Forestier, E. (författare)
-
visa fler...
-
- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
-
Clausen, N. (författare)
-
- Heldrup, Jesper (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Hovi, L. (författare)
-
Jonmundsson, G. (författare)
-
Lie, S. O. (författare)
-
Glomstein, A. (författare)
-
Hasle, H. (författare)
-
visa färre...
-
(creator_code:org_t)
- Wiley, 2005
- 2005
- Engelska.
-
Ingår i: Br J Haematol. - : Wiley. - 0007-1048 .- 1365-2141. ; 128:6, s. 797-804
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://onlinelibrar...
-
https://gup.ub.gu.se...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- To determine the epidemiology and outcome of children with Down syndrome (DS) diagnosed with acute leukaemia in the Nordic countries, data registered in the Nordic Society of Paediatric Haematology and Oncology (NOPHO) population-based leukaemia registry were analysed. Of 3494 children with acute leukaemia diagnosed between July 1984 and December 2001, 136 patients (3.9%) with DS were identified. 2.1% of the children with acute lymphoid leukaemia (ALL) and 14.0% of the children with acute myeloid leukaemia (AML) had DS. In ALL, DS patients had similar age and sex distribution and no major differences in blood counts compared with non-DS children. None of the DS patients had T cell leukaemia. Outcome was inferior to that of non-DS children and treatment results did not improve over time. In AML, DS patients showed a significant female predominance and all but one were <5 years old. DS patients with AML had significantly lower platelet and white blood cell counts and two-thirds were type M7 as according to the French-American-British classification. None of the patients <5 years of age had typical AML cytogenetic aberrations. Outcome was far better in the DS group. DS patients treated for AML after 1992 had an excellent outcome (probability of event-free survival, 83 +/- 6%). The high proportion of female DS patients with AML is unexplained. The differing treatment results in AML versus ALL need further evaluation and represent a challenge for the coming years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Acute Disease
- Age Distribution
- Child
- Child
- Preschool
- Disease-Free Survival
- Down Syndrome/*complications/epidemiology/therapy
- Female
- Humans
- Infant
- Infant
- Newborn
- Leukemia
- Lymphocytic
- Acute
- L1/*complications/epidemiology/therapy
- Leukemia
- Myeloid/*complications/epidemiology/therapy
- Male
- Norway/epidemiology
- children
- epidemiology
- Down syndrome
- acute lymphoid leukaemia
- acute myeloid leukaemia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Zeller, B.
-
Gustafsson, G.
-
Forestier, E.
-
Abrahamsson, Jon ...
-
Clausen, N.
-
Heldrup, Jesper
-
visa fler...
-
Hovi, L.
-
Jonmundsson, G.
-
Lie, S. O.
-
Glomstein, A.
-
Hasle, H.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Br J Haematol
- Av lärosätet
-
Göteborgs universitet
-
Lunds universitet
-
Karolinska Institutet