Off-pump CABG reduces complement activation but does not significantly affect peripheral endothelial function: a prospective randomized study.

OBJECTIVE--Cardiac surgery initiates a systemic inflammatory response, which may affect endothelial function. The aim of this study was to investigate if off-pump CABG (OPCAB) reduces the postoperative inflammatory response and affects endothelial function less than conventional on-pump CABG. DESIGN--Fifty-two patients submitted for elective CABG were included in a prospective, randomized study. Twenty-six patients were operated with, and 26 without cardiopulmonary bypass (CPB). Plasma levels of complement (C3a), cytokines (IL-8, TNF-alpha), endothelin-1 and neopterin were measured before and during surgery and 2 and 24 h after surgery. Endothelial function was assessed by forearm plethysmography and acetylcholine infusion in 30 patients 2-4 h after surgery. RESULTS--C3a and neopterin concentrations were significantly higher during and early after surgery in the CPB group while TNF-alpha and IL-8 tended to be higher in the CPB group but the difference did not reach statistical significance. Endothelial function did not differ significantly between the two groups. CONCLUSION--OPCAB reduces complement activation compared with on-pump CABG but does not significantly affect TNF-alpha and IL-8 release or endothelial function.

Nilsson, Folke,1950Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xnilfo (författare)
Bengtsson, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care(Swepub:gu)xbeand (författare)
Jeppsson, Anders,1960Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xjepan (författare)
Wiklund, Lars,1954Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xwikla (författare)
Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Ingår i:Scandinavian cardiovascular journal : SCJ: Informa UK Limited38:1, s. 53-81401-74311651-2006

Av författaren/redakt...: Johansson-Synner ...; Nilsson, Folke, ...; Bengtsson, Ander ...; Jeppsson, Anders ...; Wiklund, Lars, 1 ...

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