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Plasma metallothion...
Plasma metallothionein antibody and cadmium-induced renal dysfunction in an occupational population in China.
- Artikel/kapitelEngelska2006
Förlag, utgivningsår, omfång ...
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2005-12-01
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Oxford University Press (OUP),2006
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LIBRIS-ID:oai:gup.ub.gu.se/53610
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https://gup.ub.gu.se/publication/53610URI
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https://doi.org/10.1093/toxsci/kfj053DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-5742URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1949962URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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It has been reported that anti-metallothionein (a metallothionein antibody) is present in the circulation of healthy subjects and in patients suffering from atopic dermatitis. The aim of this study was to investigate whether cadmium-induced renal dysfunction is related to the presence of the plasma metallothionein antibody (MT-Ab) in workers exposed to cadmium (Cd) occupationally. Plasma metallothionein antibody was determined by enzyme linked immunosorbent assay (ELISA) techniques, and both exposure assessment and risk assessment were conducted in cadmium-exposed workers in China. We demonstrate that there is a significantly increased prevalence of renal dysfunction with respect to the level of urinary cadmium in a dose-dependent manner. We found no significant correlations between the levels of MT-Ab and the external or internal exposure doses of cadmium (p > 0.05), but the levels of MT-Ab did correlate positively with two biomarkers of renal dysfunction-urinary beta2-microglobulin (UB2M; r = 0.218, p < 0.05) and N-acetyl-beta-D-glucosaminidase (UNAG; r = 0.302, p < 0.001)-in the cadmium-exposed workers. Workers who have high levels of MT-Ab display cadmium-induced tubular nephrotoxicity more frequently than those possessing low levels of MT-Ab; odds ratio (OR) 4.2; 95% confidence intervals 1.2-14.5 (p < 0.05). This study suggests that subjects that have higher MT-Ab levels more readily develop cadmium-induced renal dysfunction. Thus, the levels of plasma MT-Ab can be used as a biomarker of susceptibility to renal dysfunction in occupational cadmium exposure.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jin, Taiyi
(författare)
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Huang, Bo
(författare)
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Chang, Xiuli
(författare)
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Lei, Lijian
(författare)
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Nordberg, Gunnar,1945Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Yrkes- och miljömedicin(Swepub:umu)guno0001
(författare)
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Nordberg, MonicaKarolinska Institutet
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Toxicological sciences : an official journal of the Society of Toxicology: Oxford University Press (OUP)91:1, s. 104-121096-6080
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Ingår i:Toxicological Sciences: Oxford University Press (OUP)91:1, s. 104-121096-0929
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