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Is interleukin-18 u...
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Bokarewa, Maria,1963Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
(författare)
Is interleukin-18 useful for monitoring rheumatoid arthritis?
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
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2009-07-12
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Informa UK Limited,2005
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/53878
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https://gup.ub.gu.se/publication/53878URI
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https://doi.org/10.1080/03009740510026724DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE: Interleukin-18 (IL-18) is a proinflammatory regulator of immune responses. Its similarities to IL-1beta and ability to induce tumour necrosis factor-alpha (TNF-alpha) make it potentially important in the pathogenesis of rheumatoid arthritis (RA). METHODS: The level of IL-18 was assessed in matched pairs of blood and synovial fluid samples from 90 RA patients (47 erosive, 43 non-erosive) by an enzyme-linked immunosorbent assay (ELISA), and the results compared to 40 healthy controls. RESULTS: In RA patients with erosive joint disease, the IL-18 level was higher than that in non-erosive RA [(median+/-QR) blood: 385+/-200 vs. 235+/-183 pg/mL, p = 0.02; synovial fluid: 392+/-392 vs. 224+/-324 pg/mL, p = 0.05]. IL-18 levels in blood of RA patients were similar and closely related to the local, intra-articular level (r = 0.96). The IL-18 level was not related to other markers of inflammation, to the duration of RA, or to the treatment modality. The IL-18 level in RA patients was similar to that of the controls (278+/-234 vs. 344+/-179 pg/mL, not significant). CONCLUSIONS: An increased IL-18 level is associated with erosive joint disease, but the measurement of IL-18 does not help to distinguish between RA patients and healthy controls.
Ämnesord och genrebeteckningar
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Arthritis
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Rheumatoid
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blood
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Biological Markers
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blood
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Interleukin-18
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blood
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Male
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Middle Aged
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Monitoring
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Immunologic
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methods
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Synovial Fluid
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metabolism
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hultgren, Olof H.,1970Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology(Swepub:gu)xhulol
(författare)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian journal of rheumatology: Informa UK Limited34:6, s. 433-60300-97421502-7732
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