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Microwave-assisted ...
Microwave-assisted solid-phase synthesis of 2,5-diketopiperazines: solvent and resin dependence.
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- Tullberg, Marcus, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Luthman, Kristina, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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- Grøtli, Morten, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry
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(creator_code:org_t)
- 2006-10-26
- 2006
- Engelska.
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Ingår i: Journal of combinatorial chemistry. - : American Chemical Society (ACS). - 1520-4766 .- 1520-4774. ; 8:6, s. 915-22
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Solid-phase synthesis of diketopiperazines (DKPs) was preformed using various combinations of resins (polystyrene, TentaGel, ArgoGel, and PEGA) and solvents (toluene, tert-butyl alcohol, water, and toluene/2-butanol (1:4, v/v). The DKPs were synthesized from solid-phase bound dipeptides via intramolecular aminolysis. Both thermal and microwave-assisted solid-phase synthesis of DKPs gave high yields of products independently of resin and organic solvent used; however, only the PEGA resin resulted in high yields of DKPs in water independent of heating method. The short reaction times, high yields, and the possibility to run reactions in water when an appropriate resin is used makes the microwave-assisted solid-phase synthesis the method of choice. The method should be suitable for solid-phase synthesis of diketopiperazine-based libraries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Combinatorial Chemistry Techniques
- methods
- Cyclization
- Microwaves
- Molecular Structure
- Piperazines
- chemical synthesis
- chemistry
- radiation effects
- Resins
- Synthetic
- chemistry
- radiation effects
- Solvents
- chemistry
- radiation effects
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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