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Chromosomal changes...
Chromosomal changes associated with clinical outcome in lymph node-negative breast cancer.
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- Karlsson, Elin, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden
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- Danielsson, Anna, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden
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- Delle, Ulla, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden
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- Olsson, Björn (författare)
- Högskolan i Skövde,Institutionen för kommunikation och information
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- Karlsson, Per, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Oncology Section, Department of Oncology, Sahlgrenska University Hospital, Blå stråket 2, SE-413 45 Göteborg, Sweden
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- Helou, Khalil, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology, Institute of Clinical Sciences, Göteborg University, Blå stråket 2, SE-413 45 Göteborg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Cancer genetics and cytogenetics. - : Elsevier BV. - 0165-4608 .- 1873-4456. ; 172:2, s. 139-46
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Breast cancer is the most common malignancy among women and accounts for over one million new cases worldwide per year. Lymph node-negative breast cancer patients are reputed as having a better prognosis than lymph node-positive ones. Around 20% of the lymph node-negative patients die within 10 years after diagnosis. To improve the prognostics of node-negative breast cancer, it is important to understand the underlying biologic mechanisms promoting survival, such as specific genetic changes in the tumor genome. In this study, CGH was applied to analyze 64 tumors from node-negative breast cancer patients to identify DNA copy number changes in chromosomes and chromosome regions that may be correlated to survival. The main findings show gains at 4q, 5q31 approximately qter, 6q12 approximately q16, and 12q14 approximately q22, as well as losses of 17p, 18p, and Xq, which were significantly more recurrent in tumors from deceased patients than in tumors from survivors. The average number of chromosomal changes was higher in the tumors from deceased compared to the survivor tumors. Our findings suggest that tumors with specific chromosomal aberrations at 4q, 5q31 approximately qter, 6q12 approximately q16, 12q14 approximately q22, 17p, 18p, and Xq result in an aggressive form of breast cancer and that these patients are predisposed to succumb to breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adult
- Aged
- Breast Neoplasms
- genetics
- mortality
- pathology
- surgery
- Chromosome Aberrations
- Female
- Humans
- Lymph Nodes
- pathology
- Middle Aged
- Prognosis
- Risk Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Karlsson, Elin, ...
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Danielsson, Anna ...
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Delle, Ulla, 195 ...
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Olsson, Björn
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Karlsson, Per, 1 ...
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Helou, Khalil, 1 ...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer genetics ...
- Av lärosätet
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Göteborgs universitet
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Högskolan i Skövde