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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04169naa a2200529 4500 | |
| 001 | oai:gup.ub.gu.se/56222 | |
| 003 | SwePub | |
| 008 | 240528s2005 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:b3bc7600-3e1c-41e3-8c03-35bc606e5522 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/562222 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ijcard.2004.10.0052 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/1361342 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Erlinge, Davidu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kard-der |
| 245 | 1 0 | a Uridine triphosphate (UTP) is released during cardiac ischemia |
| 264 | 1 | b Elsevier BV,c 2005 |
| 520 | a BACKGROUND: Extracellular uridine triphosphate (UTP) stimulates vasodilatation, automaticity in ventricular myocytes and release of tissue-plasminogen activator (t-PA), indicating that UTP may be important in cardiac regulation. We took advantage of a recently developed quantitative assay for UTP to test the hypothesis that UTP is released in the circulation during cardiac ischemia. METHODS: In ten pigs, a balloon catheter in the left anterior descending artery was introduced to induce ischemia. Samples were collected from the coronary sinus. Blood flow in the coronary sinus was assessed by a Doppler velocity transducer. RESULTS: Plasma UTP levels increased early during ischemia and early after reperfusion (by 257+/-100 and 247+/-72%, p<0.05). Cardiac blood flow, ventricular arrhythmias and t-PA release were markedly increased at the same time points. In contrast, after 30 min, a second period of ischemia did not result in any significant increase of UTP or blood flow. Furthermore, ventricular arrhythmias were less frequent. UTP levels correlated with ventricular arrhythmia and blood flow. Similar results were found for ATP. CONCLUSION: For the first time we have shown that UTP is released during cardiac ischemia. UTP released during ischemia may stimulate blood flow, arrhythmia and t-PA release. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Animals | |
| 653 | a Female | |
| 653 | a Heart/physiopathology | |
| 653 | a Ischemic Preconditioning | |
| 653 | a Myocardial | |
| 653 | a Male | |
| 653 | a Myocardial Ischemia/*enzymology/physiopathology | |
| 653 | a Myocardial Reperfusion | |
| 653 | a Regional Blood Flow | |
| 653 | a Swine | |
| 653 | a Tissue Plasminogen Activator/blood | |
| 653 | a Uridine Triphosphate/*blood | |
| 700 | 1 | a Harnek, Janu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)drad-jha |
| 700 | 1 | a van Heusden, C.4 aut |
| 700 | 1 | a Olivecrona, Göranu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kard-gol |
| 700 | 1 | a Jern, Sverker,d 1954u Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute4 aut0 (Swepub:gu)xjersv |
| 700 | 1 | a Lazarowski, E.4 aut |
| 710 | 2 | a Kardiologib Sektion II4 org |
| 773 | 0 | t Int J Cardiold : Elsevier BVg 100:3, s. 427-33q 100:3<427-33x 0167-5273 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15837087y FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1016/j.ijcard.2004.10.005y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/56222 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ijcard.2004.10.005 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/136134 |
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