Sökning: onr:"swepub:oai:gup.ub.gu.se/56621" >
Prevalence of antib...
Prevalence of antibodies against herpes simplex virus types 1 and 2 in children and young people in an urban region in Tanzania.
-
Kasubi, Mabula Joseph (författare)
-
Nilsen, Arvid (författare)
-
Marsden, Howard S (författare)
-
visa fler...
-
- Bergström, Tomas, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
Langeland, Nina (författare)
-
Haarr, Lars (författare)
-
visa färre...
-
(creator_code:org_t)
- 2006
- 2006
- Engelska.
-
Ingår i: Journal of clinical microbiology. - 0095-1137. ; 44:8, s. 2801-7
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Herpes simplex virus type 1 (HSV-1) is transmitted by close contact, both sexual and nonsexual, and infections are acquired during childhood and adolescence. Herpes simplex virus type 2 (HSV-2), however, is thought to be transmitted mainly by sexual contact. Most HSV-2 infections are consequently expected to occur after the onset of sexual activity. Recent reports indicate an increasing prevalence of HSV-2 on the African continent, but most studies have been performed on adult cohorts. In the present study, we collected sera from Tanzanian children and young persons from 1 to 20 years old, with at least 100 individuals in each age group. Antibodies against HSV-1 and HSV-2 were detected by an in-house Western blot method which was shown to perform well in comparison with a commercial Western blot assay. Type-specific antibodies were also analyzed by two noncommercial enzyme-linked immunosorbent assay methods based upon the antigenicities of branched synthetic oligopeptides corresponding to epitopes in glycoprotein G of HSV-1 or HSV-2. The prevalence of HSV-1 antibodies increased gradually from 73% for the age group of 1 to 4 years to 92% for the age group of 17 to 20 years. The prevalence of HSV-2 antibodies was unexpectedly high, as 15% of the children were infected by the age of 8 years, with the incidence increasing gradually to 40% in the age group of 17 to 20 years. The reason for this unexpectedly high frequency is not clear but could suggest that nonsexual transmission of HSV-2 is more common than previously thought. There was no statistically significant association between seropositivities for HSV-2 and human immunodeficiency virus.
Nyckelord
- Adolescent
- Adult
- Antibodies
- Viral
- blood
- Blotting
- Western
- Child
- Child
- Preschool
- Enzyme-Linked Immunosorbent Assay
- Female
- HIV
- immunology
- Herpes Simplex
- epidemiology
- virology
- Herpesvirus 1
- Human
- immunology
- Herpesvirus 2
- Human
- immunology
- Humans
- Infant
- Male
- Seroepidemiologic Studies
- Statistics
- Tanzania
- epidemiology
- Urban Population
- statistics & numerical data
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas