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Factors important f...
Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries.
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- Baumann, Pia (författare)
- Karolinska Institutet
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- Nyman, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Lax, Ingmar (författare)
- Karolinska Institutet
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- Friesland, Signe (författare)
- Karolinska Institutet
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Hoyer, Morten (författare)
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Rehn Ericsson, Suzanne (författare)
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- Johansson, Karl-Axel (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Ekberg, Lars (författare)
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Morhed, Elisabeth (författare)
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Paludan, Merete (författare)
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- Wittgren, Lena (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Blomgren, Henrik (författare)
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- Lewensohn, Rolf (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-07-08
- 2006
- Engelska.
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Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 45:7, s. 787-95
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We reviewed results of SBRT treatment of 138 patients with medically inoperable stage I NSCLC treated during 1996-2003 at five different centres in Sweden and Denmark. Mean age was 74 years (range 56-90) with 69 men and 72 women. SBRT was delivered using a 3D conformal multifield technique and a stereotactic body frame. Doses delivered were 30-48 Gy (65% isodose at the periphery of planning target volume, PTV) in 2-4 fractions. Equivalent dose in 2 Gy fractions (EQD2) was in the range of 50-100 Gy. Mean gross tumour volume (GTV) was 39 cm3 (2-436), and planning target volume was 101 cm3 (11-719). Overall response rate (CR, PR) was 61% (84/138). SD was noted in 36% (50/138). During a median follow-up period of 33 months (1-107), 16 (12%) local failures occurred, ten of which also included distant metastases. Local failure was associated with tumour size, target definition and central or pleura proximity. Distant metastases occurred in 25% (35/138) of the patients. Ninety-one (65%) patients died during follow-up of which 55 patients (60%) died of other causes than lung cancer. Three- and 5-year overall survival was 52 and 26% respectively. Lung cancer specific 3- and 5-year overall survival was 66 and 40% respectively. Fifty nine percent (83/138) of the patients had no side effects. Fourteen patients experienced grade 3-4 toxicity according to radiation therapy oncology group (RTOG). EQD2 (> v.s.<55.6 Gy) showed a statistically significant benefit survival for the higher doses. SBRT for stage I NSCLC results in favourable local control not inferior to fractionated RT and with acceptable toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Aged
- Aged
- 80 and over
- Carcinoma
- Non-Small-Cell Lung
- mortality
- pathology
- surgery
- Denmark
- epidemiology
- Disease-Free Survival
- Female
- Humans
- Lung Neoplasms
- mortality
- pathology
- surgery
- Male
- Middle Aged
- Neoplasm Metastasis
- therapy
- Neoplasm Recurrence
- Local
- mortality
- Probability
- Radiosurgery
- methods
- Retrospective Studies
- Survival Analysis
- Sweden
- epidemiology
- Treatment Failure
- Treatment Outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Baumann, Pia
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Nyman, Jan, 1956
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Lax, Ingmar
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Friesland, Signe
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Hoyer, Morten
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Rehn Ericsson, S ...
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visa fler...
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Johansson, Karl- ...
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Ekberg, Lars
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Morhed, Elisabet ...
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Paludan, Merete
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Wittgren, Lena
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Blomgren, Henrik
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Lewensohn, Rolf
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Acta oncologica ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet
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Karolinska Institutet