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Deriving evolutiona...
Deriving evolutionary tree models of the oncogenesis of endometrial adenocarcinoma.
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- Chen, Lei (författare)
- Högskolan i Skövde,Institutionen för kommunikation och information
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- Nordlander, Carola, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,CMB-Genetics, Lundberg Laboratory, Göteborg University, Sweden
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- Behboudi, Afrouz, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,CMB-Genetics, Lundberg Laboratory, Göteborg University, Sweden
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- Olsson, Björn (författare)
- Högskolan i Skövde,Institutionen för kommunikation och information
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- Klinga Levan, Karin (författare)
- Högskolan i Skövde,Institutionen för vård och natur
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(creator_code:org_t)
- 2006
- 2007
- Engelska.
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Ingår i: International journal of cancer. Journal international du cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 120:2, s. 292-6
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Endometrial adenocarcinoma (EAC) is the fourth leading cause of cancer death in women worldwide, but not much is known about the underlying genetic factors involved in the development of this complex disease. In the present work, we used 3 different algorithms to derive tree models of EAC oncogenesis from data on the frequencies of genomic alterations in rat chromosome 10 (RNO10). The tumor material was derived from progenies of crosses between the EAC susceptible BDII inbred rat strain and two non susceptible inbred rat strains. Data from allelic imbalance scans of RNO10 with microsatellite markers on solid tumor material and corresponding tissue cultures were used. For the analysis, RNO10 was divided into 24 segments containing a total of 59 informative microsatellite markers. The derived tree models show that genomic alterations have occurred in 11 of the 24 segments. In addition, the models provide information about the likely order of the alterations as well as their relationship with each other. Interestingly, there was a high degree of consistency among the different tree models and with the results of previous studies, which supports the reliability of the tree models. Our results may be extended into a general approach for tree modeling of whole genome alterations during oncogenesis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adenocarcinoma
- genetics
- Algorithms
- Allelic Imbalance
- Animals
- Chromosomes
- genetics
- Endometrial Neoplasms
- genetics
- Evolution
- Molecular
- Female
- Humans
- Models
- Genetic
- Rats
- oncogenesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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