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Beneficial effect o...
Beneficial effect of angiotensin-converting enzyme inhibitor on dilated cardiomyopathy induced by autoimmune mechanism against beta1-adrenoceptor.
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Matsui, S (författare)
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- Fu, Michael, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Wallenberglaboratoriet,Institute of Internal Medicine,Wallenberg Laboratory
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Hayase, M (författare)
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visa fler...
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Katsuda, T (författare)
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Yamaguchi, N (författare)
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Teraoka, K (författare)
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Kurihara, T (författare)
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Takekoshi, N (författare)
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Wakabayashi, H (författare)
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visa färre...
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Journal of cardiovascular pharmacology. - 0160-2446. ; 36 Suppl 2
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- We have shown that a peptide corresponding to the sequence of the second extracellular loop of the human beta1-adrenoceptor (beta1-peptide) was able to induce an autoimmune cardiomyopathy in rabbits. In this study, we examined the effect of angiotensin-converting enzyme inhibitor (ACEI) on beta1-peptide-induced cardiomyopathy. Rabbits were divided into four groups: (1) control group (n= 6) receiving saline injection; (2) beta1-peptide group (n = 8) immunized with beta1-peptide; (3) ACEI group (n = 6), lisinopril (3 mg/day) given orally and receiving saline injection; and (4) ACEI + beta1-peptide group (n = 7), lisinopril (3 mg/day) given orally and immunized with beta1-peptide. Our results showed that, after 1 year, all rabbits in the beta1-peptide group had an increase in heart weight, wall thinning and dilatations of both ventricles as compared with rabbits in the ACEI + beta1-peptide group that had normal heart weight and shape. All rabbits in the beta1-peptide group exhibited multifocal degeneration and necrosis of myocardial cells with moderate infiltration of inflammatory cells. In the ACEI + beta1-peptide group, three rabbits showed focal degeneration and necrosis of myocardial cells accompanied by mononuclear cells. The lesions in this group were apparently less marked than those in the beta1-peptide group. In conclusion, ACEI protects the myocardium from injury induced by an autoimmune mechanism against beta1-adrenoceptor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Amino Acid Sequence
- Angiotensin-Converting Enzyme Inhibitors
- therapeutic use
- Animals
- Autoimmunity
- Body Weight
- drug effects
- Cardiomyopathy
- Dilated
- drug therapy
- etiology
- Enzyme-Linked Immunosorbent Assay
- Immunization
- Lisinopril
- blood
- therapeutic use
- Microscopy
- Electron
- Molecular Sequence Data
- Myocardium
- pathology
- ultrastructure
- Organ Size
- drug effects
- Rabbits
- Receptors
- Adrenergic
- beta-1
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Matsui, S
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Fu, Michael, 196 ...
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Hayase, M
-
Katsuda, T
-
Yamaguchi, N
-
Teraoka, K
-
visa fler...
-
Kurihara, T
-
Takekoshi, N
-
Wakabayashi, H
-
visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Göteborgs universitet